Symptom clustering in patients with childhood-onset systemic lupus erythematosus

Yi Chien Chiang, Jing Long Huang*, Chao Hui Wang, Hsiang Chun Lee, Ming Ying Lee, Ya Chu Hsiao

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

6 Scopus citations


Aims: To: (a) explore the prevalence of the symptoms perceived by patients with childhood-onset systemic lupus erythematosus; (b) identify the symptom clusters occurring in patients with childhood-onset Systemic lupus erythematosus; and (c) examine the association of the burden of each symptom cluster with sleep quality and depression. Background: Systemic lupus erythematosus is an inflammatory autoimmune disease that may result in patients' perception of various symptoms, with possible negative effects on their quality of life. Understanding the prevalence of symptoms perceived by childhood-onset Systemic lupus erythematosus patients and the disease's symptom clusters may be helpful in managing such burdensome symptoms. Design: A correlational study design was used for this study in 2016. Methods: Self-reported data from the Systemic lupus erythematosus symptom checklist were used to assess the symptoms perceived by patients. Symptom clusters were analysed using cluster analysis. Results: Seventy-five patients were included in this study. The most prevalent and burdensome symptom perceived by patients was fatigue. Five clusters were derived, including symptoms related to pain and itching; bruises and stomach complaints; weight gain; body image and circulatory problems; and fatigue. A poor sleeper may perceive a greater symptom burden in all five of the symptom clusters, except for cluster #3, which refers to symptoms related to weight gain. Conclusion: Five symptom clusters were identified. It is hoped that this study will give useful knowledge for understanding the symptom clusters for patients with Systemic lupus erythematosus and for improving nursing care quality.

Translated title of the contribution儿童期系统性红斑狼疮患者的症状群分析
Original languageEnglish
Pages (from-to)54-62
Number of pages9
JournalJournal of Advanced Nursing
Issue number1
StatePublished - 01 2019

Bibliographical note

Publisher Copyright:
© 2018 John Wiley & Sons Ltd


  • childhood-onset
  • nursing
  • symptom cluster
  • systemic lupus erythematosus


Dive into the research topics of 'Symptom clustering in patients with childhood-onset systemic lupus erythematosus'. Together they form a unique fingerprint.

Cite this