Syntheses of Iso‐Condensed Heteroaromatic Pyrroles

Chin‐Kang ‐K Sha*, Chiu‐Peng ‐P Tsou, Chung‐Yin ‐Y Tsai, Jia‐Ming ‐M Liu, Ren‐Sheng ‐S Lee, Yu‐Chang ‐C Li, Fu‐Yuan ‐Y Tsai, Shiow‐Jye ‐J Way, Jenn‐Jong ‐J Young, Kuang‐Sein ‐S Chuan, Ren‐Hwa ‐H Yeh

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

7 Scopus citations

Abstract

Three novel reactions for the synthesis of iso‐condensed heteroaromatic pyrroles: (1) tandem intramolecular 1,3‐dipolar cycloaddition and cycloreversion reaction; (2) phosphineimine‐alkylidenemalonate cyclization reaction; (3) retromalonate addition reaction, are described. They can be used in acidic, neutral or basic conditions respectively. Iso‐condensed heteroaromatic pyrroles, such as pyrrolo[3,4‐b]indole 12, pyrrolo[3,4‐b]pyridine 17, pyrrolo[3,4‐c]pyridine 18, thieno[2,3‐c]pyrrole 37, pyrrolo[3,4‐b]pyrrole 40, pyrrolo[3,4‐b]pyrazine 49, benzofuro[2,3‐c]pyrrole 50, 1,2‐bis[5‐thieno[2,3‐c]pyrrolyl]ethane 51, 1,4‐bis[5‐thieno[2,3‐c]pyrrolyl]benzene 52, dipyrrolo[3,4‐b;3′,4′‐d]dipyrroles 55 and 56, benzotripyrroles 62–64, and thieno[3,4‐c]pyrroles 67 and 73 are synthesized efficiently according to these methods.

Original languageEnglish
Pages (from-to)635-639
Number of pages5
JournalJournal of the Chinese Chemical Society
Volume39
Issue number6
DOIs
StatePublished - 12 1992
Externally publishedYes

Keywords

  • 5H‐thieno[2,3‐c]pyrrole
  • Benzotripyrrole
  • Bis[thieno[2,3‐c]pyrrole]
  • Dipyrrolo[3,4‐b:3′,4′‐d]pyrrole
  • Pyrrolo[3,4‐b] pyridine
  • Pyrrolo[3,4‐b]indole
  • Pyrrolo[3,4‐b]pyrrole
  • Pyrrolo[3,4‐c)pyridine
  • Thieno[3,4‐c]pyrrole

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