Synthesis, and characterization folate-conjugated photocleavable poly(4-substituted-ε-caprolactone) polymers for drug delivery

Jia You Fang, Yin Ku Lin, Shiu Wei Wang, Ren Shen Lee*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

1 Scopus citations

Abstract

Photo-cleavable polymers containing 5-hydroxy-2-nitrobenzyl alcohol (ONB) junction point between the target molecule of folic acid (FA) and the hydrophobic poly(4-substituted-ɛ-caprolactone) (PXCLn) chain were synthesized. FA –terminated ONB-PXCLn polymers formed micelles with critical micelle concentration (CMC) 1.2–64.3 mg L−1. Fluorescence emission spectroscopy indicated the release of Nile red encapsulated FA-ONB-PXCLn micelles in response to irradiation. Light-triggered bursts released were observed for drug-loaded FA-ONB-PXCLn micelles. The nanoparticles exhibited nonsignificant toxicity at concentrations up to 300 µg mL−1. Flow cytometry revealed that the uptake of folate-targeted doxorubicin (DOX) -encapsulated micelles by HeLa cells was faster than that of free DOX.

Original languageEnglish
Pages (from-to)53-63
Number of pages11
JournalInternational Journal of Polymeric Materials and Polymeric Biomaterials
Volume69
Issue number1
DOIs
StatePublished - 02 01 2020

Bibliographical note

Publisher Copyright:
© 2019, © 2019 Taylor & Francis Group, LLC.

Keywords

  • Photo-cleavable
  • folic acid
  • micellization
  • polyester
  • target

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