Synthesis and characterization of dual-stimuli-responsive micelles based on poly(N-isopropylacrylamide) and polycarbonate with photocleavable moieties

Jia You Fang; Yin Ku Lin; Shiu Wei Wang; You Chen Li; Ren Shen Lee

doi:10.1016/j.reactfunctpolym.2015.08.009

Synthesis and characterization of dual-stimuli-responsive micelles based on poly(N-isopropylacrylamide) and polycarbonate with photocleavable moieties

Jia You Fang, Yin Ku Lin, Shiu Wei Wang, You Chen Li, Ren Shen Lee^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

11 Scopus citations

Abstract

Dual-sensitive block copolymers, PNiPAAm-b-PNBTMC, were synthesized via the ring-opening polymerization of 3-methyl-3-nitrobenzyl-trimethylene carbonate (NBTMC) bearing numerous 2-nitro-benzoxycarbonyl photolabile groups with a PNiPAAm macroinitiator in the presence of an organocatalyst, 1,5,7-triazobicyclo-[4.4.0]dec-5-ene (TBD). When the polymer solutions were exposed to ultraviolet (UV) irradiation, we observed significant changes in the structure and morphology of the particles. Fluorescence spectroscopy studies revealed that the copolymers underwent micellization or dissociation transitions in water in response to temperature changes and UV irradiation. No significant toxicity of these nanoparticles was found at concentrations up to 300 μg mL^{- 1}.

Original language	English
Pages (from-to)	46-54
Number of pages	9
Journal	Reactive and Functional Polymers
Volume	95
DOIs	https://doi.org/10.1016/j.reactfunctpolym.2015.08.009
State	Published - 01 10 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier B.V.All rights resreved.

Keywords

Micelle
Photocleavable
Poly(N-isopropylamide)
Polycarbonate
Thermo-sensitive

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10.1016/j.reactfunctpolym.2015.08.009

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@article{f5a586e13e0c448184e825b7248b7081,

title = "Synthesis and characterization of dual-stimuli-responsive micelles based on poly(N-isopropylacrylamide) and polycarbonate with photocleavable moieties",

abstract = "Dual-sensitive block copolymers, PNiPAAm-b-PNBTMC, were synthesized via the ring-opening polymerization of 3-methyl-3-nitrobenzyl-trimethylene carbonate (NBTMC) bearing numerous 2-nitro-benzoxycarbonyl photolabile groups with a PNiPAAm macroinitiator in the presence of an organocatalyst, 1,5,7-triazobicyclo-[4.4.0]dec-5-ene (TBD). When the polymer solutions were exposed to ultraviolet (UV) irradiation, we observed significant changes in the structure and morphology of the particles. Fluorescence spectroscopy studies revealed that the copolymers underwent micellization or dissociation transitions in water in response to temperature changes and UV irradiation. No significant toxicity of these nanoparticles was found at concentrations up to 300 μg mL- 1.",

keywords = "Micelle, Photocleavable, Poly(N-isopropylamide), Polycarbonate, Thermo-sensitive",

author = "Fang, {Jia You} and Lin, {Yin Ku} and Wang, {Shiu Wei} and Li, {You Chen} and Lee, {Ren Shen}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier B.V.All rights resreved.",

year = "2015",

month = oct,

day = "1",

doi = "10.1016/j.reactfunctpolym.2015.08.009",

language = "英语",

volume = "95",

pages = "46--54",

journal = "Reactive and Functional Polymers",

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TY - JOUR

T1 - Synthesis and characterization of dual-stimuli-responsive micelles based on poly(N-isopropylacrylamide) and polycarbonate with photocleavable moieties

AU - Fang, Jia You

AU - Lin, Yin Ku

AU - Wang, Shiu Wei

AU - Li, You Chen

AU - Lee, Ren Shen

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Dual-sensitive block copolymers, PNiPAAm-b-PNBTMC, were synthesized via the ring-opening polymerization of 3-methyl-3-nitrobenzyl-trimethylene carbonate (NBTMC) bearing numerous 2-nitro-benzoxycarbonyl photolabile groups with a PNiPAAm macroinitiator in the presence of an organocatalyst, 1,5,7-triazobicyclo-[4.4.0]dec-5-ene (TBD). When the polymer solutions were exposed to ultraviolet (UV) irradiation, we observed significant changes in the structure and morphology of the particles. Fluorescence spectroscopy studies revealed that the copolymers underwent micellization or dissociation transitions in water in response to temperature changes and UV irradiation. No significant toxicity of these nanoparticles was found at concentrations up to 300 μg mL- 1.

AB - Dual-sensitive block copolymers, PNiPAAm-b-PNBTMC, were synthesized via the ring-opening polymerization of 3-methyl-3-nitrobenzyl-trimethylene carbonate (NBTMC) bearing numerous 2-nitro-benzoxycarbonyl photolabile groups with a PNiPAAm macroinitiator in the presence of an organocatalyst, 1,5,7-triazobicyclo-[4.4.0]dec-5-ene (TBD). When the polymer solutions were exposed to ultraviolet (UV) irradiation, we observed significant changes in the structure and morphology of the particles. Fluorescence spectroscopy studies revealed that the copolymers underwent micellization or dissociation transitions in water in response to temperature changes and UV irradiation. No significant toxicity of these nanoparticles was found at concentrations up to 300 μg mL- 1.

KW - Micelle

KW - Photocleavable

KW - Poly(N-isopropylamide)

KW - Polycarbonate

KW - Thermo-sensitive

UR - http://www.scopus.com/inward/record.url?scp=84940470755&partnerID=8YFLogxK

U2 - 10.1016/j.reactfunctpolym.2015.08.009

DO - 10.1016/j.reactfunctpolym.2015.08.009

M3 - 文章

AN - SCOPUS:84940470755

SN - 1381-5148

VL - 95

SP - 46

EP - 54

JO - Reactive and Functional Polymers

JF - Reactive and Functional Polymers

ER -

Synthesis and characterization of dual-stimuli-responsive micelles based on poly(N-isopropylacrylamide) and polycarbonate with photocleavable moieties

Abstract

Bibliographical note

Keywords

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