Synthesis and cytotoxicity testing of new amido-substituted triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) derivatives

Kumaraswamy Sorra; Chi Fen Chang; Srinivas Pusuluri; Khagga Mukkanti; Min Chiau Laiu; Bo Ying Bao; Chia Hao Su; Ta Hsien Chuang

doi:10.3390/molecules17088762

Synthesis and cytotoxicity testing of new amido-substituted triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) derivatives

Kumaraswamy Sorra, Chi Fen Chang, Srinivas Pusuluri, Khagga Mukkanti, Min Chiau Laiu, Bo Ying Bao, Chia Hao Su^*, Ta Hsien Chuang

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

7 Scopus citations

Abstract

A series of amido-substituted triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) derivatives was synthesized from isatoic anhydride, and their cytotoxicity against the MRC-5 and Mahlavu cell lines was evaluated. The results suggest that compound PBDT-7i with the meta-trifluoromethylbenzoyl substituent can selectively inhibit the growth of Mahlavu cells and has low toxicity towards MRC-5 cells.

Original language	English
Pages (from-to)	8762-8772
Number of pages	11
Journal	Molecules
Volume	17
Issue number	8
DOIs	https://doi.org/10.3390/molecules17088762
State	Published - 08 2012
Externally published	Yes

Keywords

Cytotoxicity
Lawesson's reagent
MRC-5 cells
Mahlavu celles
Triazolopyrrolobenzodiazepine

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title = "Synthesis and cytotoxicity testing of new amido-substituted triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) derivatives",

abstract = "A series of amido-substituted triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) derivatives was synthesized from isatoic anhydride, and their cytotoxicity against the MRC-5 and Mahlavu cell lines was evaluated. The results suggest that compound PBDT-7i with the meta-trifluoromethylbenzoyl substituent can selectively inhibit the growth of Mahlavu cells and has low toxicity towards MRC-5 cells.",

keywords = "Cytotoxicity, Lawesson's reagent, MRC-5 cells, Mahlavu celles, Triazolopyrrolobenzodiazepine",

author = "Kumaraswamy Sorra and Chang, {Chi Fen} and Srinivas Pusuluri and Khagga Mukkanti and Laiu, {Min Chiau} and Bao, {Bo Ying} and Su, {Chia Hao} and Chuang, {Ta Hsien}",

year = "2012",

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doi = "10.3390/molecules17088762",

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T1 - Synthesis and cytotoxicity testing of new amido-substituted triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) derivatives

AU - Sorra, Kumaraswamy

AU - Chang, Chi Fen

AU - Pusuluri, Srinivas

AU - Mukkanti, Khagga

AU - Laiu, Min Chiau

AU - Bao, Bo Ying

AU - Su, Chia Hao

AU - Chuang, Ta Hsien

PY - 2012/8

Y1 - 2012/8

N2 - A series of amido-substituted triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) derivatives was synthesized from isatoic anhydride, and their cytotoxicity against the MRC-5 and Mahlavu cell lines was evaluated. The results suggest that compound PBDT-7i with the meta-trifluoromethylbenzoyl substituent can selectively inhibit the growth of Mahlavu cells and has low toxicity towards MRC-5 cells.

AB - A series of amido-substituted triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) derivatives was synthesized from isatoic anhydride, and their cytotoxicity against the MRC-5 and Mahlavu cell lines was evaluated. The results suggest that compound PBDT-7i with the meta-trifluoromethylbenzoyl substituent can selectively inhibit the growth of Mahlavu cells and has low toxicity towards MRC-5 cells.

KW - Cytotoxicity

KW - Lawesson's reagent

KW - MRC-5 cells

KW - Mahlavu celles

KW - Triazolopyrrolobenzodiazepine

UR - http://www.scopus.com/inward/record.url?scp=84865514927&partnerID=8YFLogxK

U2 - 10.3390/molecules17088762

DO - 10.3390/molecules17088762

M3 - 文章

C2 - 22832878

AN - SCOPUS:84865514927

SN - 1420-3049

VL - 17

SP - 8762

EP - 8772

JO - Molecules

JF - Molecules

IS - 8

ER -

Synthesis and cytotoxicity testing of new amido-substituted triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) derivatives

Abstract

Keywords

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