Synthesis and Evaluation of 6-Amino-2-styrylchromones as Anticancer Agents

Ya Chen Chen; Yi Cheng Chu; Cai Wei Li; Jih Jung Chen; Tzenge Lien Shih

doi:10.1002/slct.202300685

Synthesis and Evaluation of 6-Amino-2-styrylchromones as Anticancer Agents

Ya Chen Chen
, Yi Cheng Chu
, Cai Wei Li
, Jih Jung Chen^*
, Tzenge Lien Shih^*

^*Corresponding author for this work

Tamkang University
National Yang Ming Chiao Tung University
China Medical University Taichung

Research output: Contribution to journal › Journal Article › peer-review

4 Scopus citations

Abstract

2-Styrylchromones, a C-2 styrene derivative of chromones, possess a broad spectrum of biological activity. However, 2-styrylchromones are scarce in nature but not to mention the amino-substituted styrylchromones. We have synthesized fourteen 6-amino-2-styrylchromones and evaluated their anti-cancer activity on human caucasian colon adenocarcinoma cells (HT-29). 6-Amino-2-styrylchromones and related derivatives have never been revealed their pharmacology profiles. Among the novel fourteen compounds, we reported that compound 9 h exhibited its potential with the comparable activity with 5-flurouracil (5-FU) as a referenced drug.

Original language	English
Article number	e202300685
Journal	ChemistrySelect
Volume	8
Issue number	18
DOIs	https://doi.org/10.1002/slct.202300685
State	Published - 11 05 2023
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2023 Wiley-VCH GmbH.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

2-Styrylchromone
6-Amino-2-styrylchromones
Anticancer agents
Human caucasian colon adenocarcinoma cell

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10.1002/slct.202300685

Cite this

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title = "Synthesis and Evaluation of 6-Amino-2-styrylchromones as Anticancer Agents",

abstract = "2-Styrylchromones, a C-2 styrene derivative of chromones, possess a broad spectrum of biological activity. However, 2-styrylchromones are scarce in nature but not to mention the amino-substituted styrylchromones. We have synthesized fourteen 6-amino-2-styrylchromones and evaluated their anti-cancer activity on human caucasian colon adenocarcinoma cells (HT-29). 6-Amino-2-styrylchromones and related derivatives have never been revealed their pharmacology profiles. Among the novel fourteen compounds, we reported that compound 9 h exhibited its potential with the comparable activity with 5-flurouracil (5-FU) as a referenced drug.",

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author = "Chen, \{Ya Chen\} and Chu, \{Yi Cheng\} and Li, \{Cai Wei\} and Chen, \{Jih Jung\} and Shih, \{Tzenge Lien\}",

note = "Publisher Copyright: {\textcopyright} 2023 Wiley-VCH GmbH.",

year = "2023",

month = may,

day = "11",

doi = "10.1002/slct.202300685",

language = "英语",

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}

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T1 - Synthesis and Evaluation of 6-Amino-2-styrylchromones as Anticancer Agents

AU - Chen, Ya Chen

AU - Chu, Yi Cheng

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AU - Chen, Jih Jung

AU - Shih, Tzenge Lien

PY - 2023/5/11

Y1 - 2023/5/11

N2 - 2-Styrylchromones, a C-2 styrene derivative of chromones, possess a broad spectrum of biological activity. However, 2-styrylchromones are scarce in nature but not to mention the amino-substituted styrylchromones. We have synthesized fourteen 6-amino-2-styrylchromones and evaluated their anti-cancer activity on human caucasian colon adenocarcinoma cells (HT-29). 6-Amino-2-styrylchromones and related derivatives have never been revealed their pharmacology profiles. Among the novel fourteen compounds, we reported that compound 9 h exhibited its potential with the comparable activity with 5-flurouracil (5-FU) as a referenced drug.

AB - 2-Styrylchromones, a C-2 styrene derivative of chromones, possess a broad spectrum of biological activity. However, 2-styrylchromones are scarce in nature but not to mention the amino-substituted styrylchromones. We have synthesized fourteen 6-amino-2-styrylchromones and evaluated their anti-cancer activity on human caucasian colon adenocarcinoma cells (HT-29). 6-Amino-2-styrylchromones and related derivatives have never been revealed their pharmacology profiles. Among the novel fourteen compounds, we reported that compound 9 h exhibited its potential with the comparable activity with 5-flurouracil (5-FU) as a referenced drug.

KW - 2-Styrylchromone

KW - 6-Amino-2-styrylchromones

KW - Anticancer agents

KW - Human caucasian colon adenocarcinoma cell

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DO - 10.1002/slct.202300685

M3 - 文章

AN - SCOPUS:85159049897

SN - 2365-6549

VL - 8

JO - ChemistrySelect

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IS - 18

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ER -

Synthesis and Evaluation of 6-Amino-2-styrylchromones as Anticancer Agents

Abstract

Bibliographical note

UN SDGs

Keywords

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