Synthesis of Neisseria meningitidis serogroup W135 capsular oligosaccharides for immunogenicity comparison and vaccine development

Chia Hung Wang; Shiou Ting Li; Tzu Lung Lin; Yang Yu Cheng; Tsung Hsien Sun; Jin Town Wang; Ting Jen R. Cheng; Kwok Kong Tony Mong; Chi Huey Wong; Chung Yi Wu

doi:10.1002/anie.201302540

Synthesis of Neisseria meningitidis serogroup W135 capsular oligosaccharides for immunogenicity comparison and vaccine development

Chia Hung Wang, Shiou Ting Li, Tzu Lung Lin, Yang Yu Cheng, Tsung Hsien Sun, Jin Town Wang, Ting Jen R. Cheng, Kwok Kong Tony Mong, Chi Huey Wong, Chung Yi Wu^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

57 Scopus citations

Abstract

Sweetening the deal: N.meningitidis serogroup W135 capsular oligosaccharides were synthesized in lengths from disaccharides to decasaccharides. Sera from mice immunized with these oligosaccharide-protein conjugates were examined by a glycan microarray (see picture) and bactericidal assay for antibody specificity and the ability to kill bacteria.

Original language	English
Pages (from-to)	9157-9161
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	35
DOIs	https://doi.org/10.1002/anie.201302540
State	Published - 26 08 2013
Externally published	Yes

Keywords

N. meningitidis
bactericidal
oligosaccharides
total synthesis
vaccine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.201302540

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Wang, C. H., Li, S. T., Lin, T. L., Cheng, Y. Y., Sun, T. H., Wang, J. T., Cheng, T. J. R., Mong, K. K. T., Wong, C. H., & Wu, C. Y. (2013). Synthesis of Neisseria meningitidis serogroup W135 capsular oligosaccharides for immunogenicity comparison and vaccine development. Angewandte Chemie - International Edition, 52(35), 9157-9161. https://doi.org/10.1002/anie.201302540

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abstract = "Sweetening the deal: N.meningitidis serogroup W135 capsular oligosaccharides were synthesized in lengths from disaccharides to decasaccharides. Sera from mice immunized with these oligosaccharide-protein conjugates were examined by a glycan microarray (see picture) and bactericidal assay for antibody specificity and the ability to kill bacteria.",

keywords = "N. meningitidis, bactericidal, oligosaccharides, total synthesis, vaccine",

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year = "2013",

month = aug,

day = "26",

doi = "10.1002/anie.201302540",

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AU - Wang, Chia Hung

AU - Li, Shiou Ting

AU - Lin, Tzu Lung

AU - Cheng, Yang Yu

AU - Sun, Tsung Hsien

AU - Wang, Jin Town

AU - Cheng, Ting Jen R.

AU - Mong, Kwok Kong Tony

AU - Wong, Chi Huey

AU - Wu, Chung Yi

PY - 2013/8/26

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N2 - Sweetening the deal: N.meningitidis serogroup W135 capsular oligosaccharides were synthesized in lengths from disaccharides to decasaccharides. Sera from mice immunized with these oligosaccharide-protein conjugates were examined by a glycan microarray (see picture) and bactericidal assay for antibody specificity and the ability to kill bacteria.

AB - Sweetening the deal: N.meningitidis serogroup W135 capsular oligosaccharides were synthesized in lengths from disaccharides to decasaccharides. Sera from mice immunized with these oligosaccharide-protein conjugates were examined by a glycan microarray (see picture) and bactericidal assay for antibody specificity and the ability to kill bacteria.

KW - N. meningitidis

KW - bactericidal

KW - oligosaccharides

KW - total synthesis

KW - vaccine

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U2 - 10.1002/anie.201302540

DO - 10.1002/anie.201302540

M3 - 文章

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AN - SCOPUS:84883010128

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

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ER -

Synthesis of Neisseria meningitidis serogroup W135 capsular oligosaccharides for immunogenicity comparison and vaccine development

Abstract

Keywords

UN SDGs

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