Synthesis of Neisseria meningitidis serogroup W135 capsular oligosaccharides for immunogenicity comparison and vaccine development

Chia Hung Wang; Shiou Ting Li; Tzu Lung Lin; Yang Yu Cheng; Tsung Hsien Sun; Jin Town Wang; Ting Jen R. Cheng; Kwok Kong Tony Mong; Chi Huey Wong; Chung Yi Wu

doi:10.1002/anie.201302540

Synthesis of Neisseria meningitidis serogroup W135 capsular oligosaccharides for immunogenicity comparison and vaccine development

Chia Hung Wang
, Shiou Ting Li
, Tzu Lung Lin
, Yang Yu Cheng
, Tsung Hsien Sun
, Jin Town Wang
, Ting Jen R. Cheng
, Kwok Kong Tony Mong
, Chi Huey Wong
, Chung Yi Wu^*

^*Corresponding author for this work

Academia Sinica - Genomics Research Center
National Yang Ming Chiao Tung University
National Taiwan University

Research output: Contribution to journal › Journal Article › peer-review

57 Scopus citations

Abstract

Sweetening the deal: N.meningitidis serogroup W135 capsular oligosaccharides were synthesized in lengths from disaccharides to decasaccharides. Sera from mice immunized with these oligosaccharide-protein conjugates were examined by a glycan microarray (see picture) and bactericidal assay for antibody specificity and the ability to kill bacteria.

Original language	English
Pages (from-to)	9157-9161
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	35
DOIs	https://doi.org/10.1002/anie.201302540
State	Published - 26 08 2013
Externally published	Yes

Keywords

N. meningitidis
bactericidal
oligosaccharides
total synthesis
vaccine

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10.1002/anie.201302540

Cite this

Wang, C. H., Li, S. T., Lin, T. L., Cheng, Y. Y., Sun, T. H., Wang, J. T., Cheng, T. J. R., Mong, K. K. T., Wong, C. H., & Wu, C. Y. (2013). Synthesis of Neisseria meningitidis serogroup W135 capsular oligosaccharides for immunogenicity comparison and vaccine development. Angewandte Chemie - International Edition, 52(35), 9157-9161. https://doi.org/10.1002/anie.201302540

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abstract = "Sweetening the deal: N.meningitidis serogroup W135 capsular oligosaccharides were synthesized in lengths from disaccharides to decasaccharides. Sera from mice immunized with these oligosaccharide-protein conjugates were examined by a glycan microarray (see picture) and bactericidal assay for antibody specificity and the ability to kill bacteria.",

keywords = "N. meningitidis, bactericidal, oligosaccharides, total synthesis, vaccine",

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year = "2013",

month = aug,

day = "26",

doi = "10.1002/anie.201302540",

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AU - Wang, Chia Hung

AU - Li, Shiou Ting

AU - Lin, Tzu Lung

AU - Cheng, Yang Yu

AU - Sun, Tsung Hsien

AU - Wang, Jin Town

AU - Cheng, Ting Jen R.

AU - Mong, Kwok Kong Tony

AU - Wong, Chi Huey

AU - Wu, Chung Yi

PY - 2013/8/26

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N2 - Sweetening the deal: N.meningitidis serogroup W135 capsular oligosaccharides were synthesized in lengths from disaccharides to decasaccharides. Sera from mice immunized with these oligosaccharide-protein conjugates were examined by a glycan microarray (see picture) and bactericidal assay for antibody specificity and the ability to kill bacteria.

AB - Sweetening the deal: N.meningitidis serogroup W135 capsular oligosaccharides were synthesized in lengths from disaccharides to decasaccharides. Sera from mice immunized with these oligosaccharide-protein conjugates were examined by a glycan microarray (see picture) and bactericidal assay for antibody specificity and the ability to kill bacteria.

KW - N. meningitidis

KW - bactericidal

KW - oligosaccharides

KW - total synthesis

KW - vaccine

UR - https://www.scopus.com/pages/publications/84883010128

U2 - 10.1002/anie.201302540

DO - 10.1002/anie.201302540

M3 - 文章

C2 - 23843313

AN - SCOPUS:84883010128

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 35

ER -

Synthesis of Neisseria meningitidis serogroup W135 capsular oligosaccharides for immunogenicity comparison and vaccine development

Abstract

Keywords

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