Synthesis of novel C4-benzazole naphthalimide derivatives with potent anti-tumor properties against murine melanoma

Yen Ta Lu; Tien Ling Chen; Kuo Song Chang; Chia Ming Chang; Tsai Yin Wei; Jen Wei Liu; Chih Ang Hsiao; Tzenge Lien Shih

doi:10.1016/j.bmc.2016.11.057

Synthesis of novel C4-benzazole naphthalimide derivatives with potent anti-tumor properties against murine melanoma

Yen Ta Lu
, Tien Ling Chen
, Kuo Song Chang
, Chia Ming Chang
, Tsai Yin Wei
, Jen Wei Liu
, Chih Ang Hsiao
, Tzenge Lien Shih^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

13 Scopus citations

Abstract

Novel C4-benzazole naphthalimide derivatives were synthesized and tested in vitro and in vivo as anti-cancer drugs. Among these synthetic molecules, compounds 9 and 10 exhibited cytotoxicity against murine B16F10 melanoma cells. In addition, the above-mentioned compounds significantly suppressed lung tumor metastasis with no visible sign of toxicity.

Original language	English
Pages (from-to)	789-794
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry
Volume	25
Issue number	2
DOIs	https://doi.org/10.1016/j.bmc.2016.11.057
State	Published - 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ltd

Keywords

B16F10 cells
Benzazole
MTS assay
Melanoma
Naphthalimide
Topoisomerase II

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmc.2016.11.057

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title = "Synthesis of novel C4-benzazole naphthalimide derivatives with potent anti-tumor properties against murine melanoma",

abstract = "Novel C4-benzazole naphthalimide derivatives were synthesized and tested in vitro and in vivo as anti-cancer drugs. Among these synthetic molecules, compounds 9 and 10 exhibited cytotoxicity against murine B16F10 melanoma cells. In addition, the above-mentioned compounds significantly suppressed lung tumor metastasis with no visible sign of toxicity.",

keywords = "B16F10 cells, Benzazole, MTS assay, Melanoma, Naphthalimide, Topoisomerase II",

author = "Lu, \{Yen Ta\} and Chen, \{Tien Ling\} and Chang, \{Kuo Song\} and Chang, \{Chia Ming\} and Wei, \{Tsai Yin\} and Liu, \{Jen Wei\} and Hsiao, \{Chih Ang\} and Shih, \{Tzenge Lien\}",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",

year = "2017",

doi = "10.1016/j.bmc.2016.11.057",

language = "英语",

volume = "25",

pages = "789--794",

journal = "Bioorganic and Medicinal Chemistry",

issn = "0968-0896",

publisher = "Elsevier Ltd",

number = "2",

}

TY - JOUR

T1 - Synthesis of novel C4-benzazole naphthalimide derivatives with potent anti-tumor properties against murine melanoma

AU - Lu, Yen Ta

AU - Chen, Tien Ling

AU - Chang, Kuo Song

AU - Chang, Chia Ming

AU - Wei, Tsai Yin

AU - Liu, Jen Wei

AU - Hsiao, Chih Ang

AU - Shih, Tzenge Lien

PY - 2017

Y1 - 2017

N2 - Novel C4-benzazole naphthalimide derivatives were synthesized and tested in vitro and in vivo as anti-cancer drugs. Among these synthetic molecules, compounds 9 and 10 exhibited cytotoxicity against murine B16F10 melanoma cells. In addition, the above-mentioned compounds significantly suppressed lung tumor metastasis with no visible sign of toxicity.

AB - Novel C4-benzazole naphthalimide derivatives were synthesized and tested in vitro and in vivo as anti-cancer drugs. Among these synthetic molecules, compounds 9 and 10 exhibited cytotoxicity against murine B16F10 melanoma cells. In addition, the above-mentioned compounds significantly suppressed lung tumor metastasis with no visible sign of toxicity.

KW - B16F10 cells

KW - Benzazole

KW - MTS assay

KW - Melanoma

KW - Naphthalimide

KW - Topoisomerase II

UR - https://www.scopus.com/pages/publications/85006912366

U2 - 10.1016/j.bmc.2016.11.057

DO - 10.1016/j.bmc.2016.11.057

M3 - 文章

C2 - 27939348

AN - SCOPUS:85006912366

SN - 0968-0896

VL - 25

SP - 789

EP - 794

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 2

ER -

Synthesis of novel C4-benzazole naphthalimide derivatives with potent anti-tumor properties against murine melanoma

Abstract

Bibliographical note

Keywords

UN SDGs

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