Abstract
The reaction of 5-amino-2-[2-(dimethylamino)ethyl]-6-phenyl-1 H -benzo[ de ]isoquinoline-1,3(2 H)-dione with a series of aldehydes in acidic media (phosphoric acid, trifluoromethanesulfonic acid, and trifluoroacetic acid) is described. This key step is based on the Pictet-Spengler reaction to synthesize ten novel isoquinolino[5,4- ab ]phenanthridine derivatives. The most effective acid is phosphoric acid and optimized yields were obtained. The frameworks of target compounds are unique and have never been reported.
Original language | English |
---|---|
Pages (from-to) | 1377-1382 |
Number of pages | 6 |
Journal | Synthesis (Germany) |
Volume | 51 |
Issue number | 6 |
DOIs | |
State | Published - 2019 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2019 Georg Thieme Verlag. All rights reserved.
Keywords
- Pictet-Spengler reaction
- Suzuki-Miyaura cross-coupling reaction
- homophthalimide
- isoquinoline-1 3-dione
- naphthalimide
- phenanthridine