Synthesis of short graphene oxide nanoribbons for improved biomarker detection of Parkinson's disease

Chia Liang Sun*, Chun Hao Su, Jhing Jhou Wu

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

31 Scopus citations


We demonstrate the microwave-assisted synthesis of short graphene oxide nanoribbons (GONRs) through unzipping cut multiwalled carbon nanotubes (MWCNTs). Transmission electron microscopy and dynamic light scattering spectroscopy were used to examine the length, size, and morphology, i. e. unzipping level, of our various products. The nanotube core and nanoribbon shell can be observed from short GONRs via a modified unzipping recipe. Then the short GONRs were adopted to modify the glassy carbon electrode for the electrochemical detection of ascorbic acid (AA), uric acid (UA), and dopamine (DA). Compared to other nanomaterials, cyclic voltammograms of short GONRs show higher anodic oxidation currents for AA, UA, and DA. The detection limits of three analytes are 26, 98, and 24nM, respectively, in amperometric current-time measurements. Especially, the sensitivity for DA is improved to be 40.86μAμM-1cm-2. The improved detection signals are due to the increased active sites of the open ends of short GONRs. Moreover, the width side of short GONRs could be more active than their length side. All above-mentioned results reveal that the short GONRs can provide a novel platform for electrochemically biomarker detection of Parkinson's disease. •Short GONRs were unzipped from cut MWCNTs.•The sensitivity for dopamine is 40.86μAμM-1cm-2.•The detection limit for dopamine is 24nM.•The improved signals are due to the open ends of short GONRs.

Original languageEnglish
Pages (from-to)334-341
Number of pages8
JournalBiosensors and Bioelectronics
StatePublished - 05 05 2015

Bibliographical note

Publisher Copyright:
© 2014 Elsevier B.V.


  • Ascorbic acid
  • Dopamine
  • Graphene oxide nanoribbon
  • Multiwalled carbon nanotube
  • Unzipping
  • Uric acid


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