TY - JOUR
T1 - Synthesis of short graphene oxide nanoribbons for improved biomarker detection of Parkinson's disease
AU - Sun, Chia Liang
AU - Su, Chun Hao
AU - Wu, Jhing Jhou
N1 - Publisher Copyright:
© 2014 Elsevier B.V.
PY - 2015/5/5
Y1 - 2015/5/5
N2 - We demonstrate the microwave-assisted synthesis of short graphene oxide nanoribbons (GONRs) through unzipping cut multiwalled carbon nanotubes (MWCNTs). Transmission electron microscopy and dynamic light scattering spectroscopy were used to examine the length, size, and morphology, i. e. unzipping level, of our various products. The nanotube core and nanoribbon shell can be observed from short GONRs via a modified unzipping recipe. Then the short GONRs were adopted to modify the glassy carbon electrode for the electrochemical detection of ascorbic acid (AA), uric acid (UA), and dopamine (DA). Compared to other nanomaterials, cyclic voltammograms of short GONRs show higher anodic oxidation currents for AA, UA, and DA. The detection limits of three analytes are 26, 98, and 24nM, respectively, in amperometric current-time measurements. Especially, the sensitivity for DA is improved to be 40.86μAμM-1cm-2. The improved detection signals are due to the increased active sites of the open ends of short GONRs. Moreover, the width side of short GONRs could be more active than their length side. All above-mentioned results reveal that the short GONRs can provide a novel platform for electrochemically biomarker detection of Parkinson's disease. •Short GONRs were unzipped from cut MWCNTs.•The sensitivity for dopamine is 40.86μAμM-1cm-2.•The detection limit for dopamine is 24nM.•The improved signals are due to the open ends of short GONRs.
AB - We demonstrate the microwave-assisted synthesis of short graphene oxide nanoribbons (GONRs) through unzipping cut multiwalled carbon nanotubes (MWCNTs). Transmission electron microscopy and dynamic light scattering spectroscopy were used to examine the length, size, and morphology, i. e. unzipping level, of our various products. The nanotube core and nanoribbon shell can be observed from short GONRs via a modified unzipping recipe. Then the short GONRs were adopted to modify the glassy carbon electrode for the electrochemical detection of ascorbic acid (AA), uric acid (UA), and dopamine (DA). Compared to other nanomaterials, cyclic voltammograms of short GONRs show higher anodic oxidation currents for AA, UA, and DA. The detection limits of three analytes are 26, 98, and 24nM, respectively, in amperometric current-time measurements. Especially, the sensitivity for DA is improved to be 40.86μAμM-1cm-2. The improved detection signals are due to the increased active sites of the open ends of short GONRs. Moreover, the width side of short GONRs could be more active than their length side. All above-mentioned results reveal that the short GONRs can provide a novel platform for electrochemically biomarker detection of Parkinson's disease. •Short GONRs were unzipped from cut MWCNTs.•The sensitivity for dopamine is 40.86μAμM-1cm-2.•The detection limit for dopamine is 24nM.•The improved signals are due to the open ends of short GONRs.
KW - Ascorbic acid
KW - Dopamine
KW - Graphene oxide nanoribbon
KW - Multiwalled carbon nanotube
KW - Unzipping
KW - Uric acid
UR - http://www.scopus.com/inward/record.url?scp=84922235870&partnerID=8YFLogxK
U2 - 10.1016/j.bios.2014.08.046
DO - 10.1016/j.bios.2014.08.046
M3 - 文章
C2 - 25201013
AN - SCOPUS:84922235870
SN - 0956-5663
VL - 67
SP - 334
EP - 341
JO - Biosensors and Bioelectronics
JF - Biosensors and Bioelectronics
ER -