Systematic review of the clinical performance of connective tissue graft and guided tissue regeneration in the treatment of gingival recessions of miller's classification grades I and II

Background/Purpose: The objective of this meta-analysis was to assess and compare the effectiveness of connective tissue graft (CTG) and guided tissue regeneration (GTR) in treating patients with gingival recessions of Miller's classification grades I and II. Methods: Nineteen clinical studies that met prestated inclusion criteria were screened from 250 initial articles for the systematic analysis of the clinical efficacies of CTG and GTR according to four clinical variables: recession depth reduction; clinical attachment gain; keratinized tissue gain; and probing depth reduction. The heterogeneity and weighted mean difference were calculated using a statistical package for meta-analysis. Results: In the follow-up period shorter than 12 months, CTG resulted in more keratinized tissue than GTR (p < 0.05). In the follow-up period of 12 months or longer, CTG resulted in significantly greater reduction in recession depth, more keratinized tissue gain, and less probing depth reduction than GTR (p < 0.05). Conclusion: With regard to recession depth reduction and keratinized tissue gain in the treatment of Miller's class I or II gingival recession, CTG was statistically significantly more effective than GTR.