TY - JOUR
T1 - Systemic effects of platelet-rich plasma local injection on serum and urinary anabolic metabolites
T2 - A prospective randomized study
AU - Kuo, Shu Jui
AU - Chou, Wen Yi
AU - Hsu, Chieh Cheng
AU - Chang-Chien, Guo Ping
AU - Lin, Su Fan
AU - Siu, Kai Kit
AU - Tsai, Tsai Chan
AU - Ko, Jih Yang
AU - Sun, Yi
N1 - Publisher Copyright:
© 2020 Wolters Kluwer Medknow Publications. All rights reserved.
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Platelet-rich plasma (PRP) is widely utilized in the treatment of sports injuries. However, potential systemic effects after localized PRP injection are unclear at present. In this prospective randomized study, 24 Taiwanese male athletes with tendinopathy were randomized into a PRP group (n = 13) or a saline group (n = 11). The concentrations of serum and urine biomarkers were quantified by enzyme-linked immunosorbent assay assessment as well as gas chromatographic and mass spectrometric analysis, respectively. The results showed no significant differences in serum levels of growth hormone, insulin-like growth factor-1, insulin-like growth factor-binding protein 3, vascular endothelial growth factor, platelet-derived growth factor-BB, or serum substance P(SP) between the two groups before intervention, nor at 1, 2, or 7 days after intervention. However, a significant decrease in the serum SP level 1 and 7 days after PRP injection was observed. Regarding urinary concentrations of metabolites of anabolic androgenic steroids (AAS), no between-group differences before intervention, nor at 1, 2, or 7 days after intervention, were observed. Our study failed to observe significant surge of serum anabolic molecules and urinary excretion of anabolic AAS metabolites after PRP injection.
AB - Platelet-rich plasma (PRP) is widely utilized in the treatment of sports injuries. However, potential systemic effects after localized PRP injection are unclear at present. In this prospective randomized study, 24 Taiwanese male athletes with tendinopathy were randomized into a PRP group (n = 13) or a saline group (n = 11). The concentrations of serum and urine biomarkers were quantified by enzyme-linked immunosorbent assay assessment as well as gas chromatographic and mass spectrometric analysis, respectively. The results showed no significant differences in serum levels of growth hormone, insulin-like growth factor-1, insulin-like growth factor-binding protein 3, vascular endothelial growth factor, platelet-derived growth factor-BB, or serum substance P(SP) between the two groups before intervention, nor at 1, 2, or 7 days after intervention. However, a significant decrease in the serum SP level 1 and 7 days after PRP injection was observed. Regarding urinary concentrations of metabolites of anabolic androgenic steroids (AAS), no between-group differences before intervention, nor at 1, 2, or 7 days after intervention, were observed. Our study failed to observe significant surge of serum anabolic molecules and urinary excretion of anabolic AAS metabolites after PRP injection.
KW - Anabolic androgenic steroids
KW - platelet-rich plasma
KW - substance P
UR - http://www.scopus.com/inward/record.url?scp=85099031499&partnerID=8YFLogxK
U2 - 10.4103/CJP.CJP_86_20
DO - 10.4103/CJP.CJP_86_20
M3 - 文章
C2 - 33380614
AN - SCOPUS:85099031499
SN - 0304-4920
VL - 63
SP - 294
EP - 300
JO - Chinese Journal of Physiology
JF - Chinese Journal of Physiology
IS - 6
M1 - 304862
ER -