Systemic effects of platelet-rich plasma local injection on serum and urinary anabolic metabolites: A prospective randomized study

Shu Jui Kuo, Wen Yi Chou, Chieh Cheng Hsu, Guo Ping Chang-Chien, Su Fan Lin, Kai Kit Siu, Tsai Chan Tsai, Jih Yang Ko*, Yi Sun

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

2 Scopus citations

Abstract

Platelet-rich plasma (PRP) is widely utilized in the treatment of sports injuries. However, potential systemic effects after localized PRP injection are unclear at present. In this prospective randomized study, 24 Taiwanese male athletes with tendinopathy were randomized into a PRP group (n = 13) or a saline group (n = 11). The concentrations of serum and urine biomarkers were quantified by enzyme-linked immunosorbent assay assessment as well as gas chromatographic and mass spectrometric analysis, respectively. The results showed no significant differences in serum levels of growth hormone, insulin-like growth factor-1, insulin-like growth factor-binding protein 3, vascular endothelial growth factor, platelet-derived growth factor-BB, or serum substance P(SP) between the two groups before intervention, nor at 1, 2, or 7 days after intervention. However, a significant decrease in the serum SP level 1 and 7 days after PRP injection was observed. Regarding urinary concentrations of metabolites of anabolic androgenic steroids (AAS), no between-group differences before intervention, nor at 1, 2, or 7 days after intervention, were observed. Our study failed to observe significant surge of serum anabolic molecules and urinary excretion of anabolic AAS metabolites after PRP injection.

Original languageEnglish
Article number304862
Pages (from-to)294-300
Number of pages7
JournalChinese Journal of Physiology
Volume63
Issue number6
DOIs
StatePublished - 01 11 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 Wolters Kluwer Medknow Publications. All rights reserved.

Keywords

  • Anabolic androgenic steroids
  • platelet-rich plasma
  • substance P

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