Abstract
Androgen receptor (AR) is a nuclear transcription factor of the hormone receptor family. For
some prostate cancers, named AR-dependent prostate cancer, it plays an important role for the
development and progress of prostate cancer. In this study, we showed 0.1μM tanshinone IIA can
inhibit the expression of mRNA and protein level in AR downstream proteins. It suggests tanshinone
IIA can block the transcriptional activity of activated ARs by lower concentration. We also showed
tanshinone IIA can suppress stability of AR protein, but not the mRNA level of AR. We also found
tanshinone IIA can inhibit the growth of LNCaP cells, AR-dependent prostate cancer cell line. This
inhibitory effect is stronger on LNCaP cells stimulated by dihydrotestosterone (DHT) than without
DHT, suggesting that tanshinone IIA can inhibit the growth of LNCaP cells through affecting the
function of AR. In summary, we discovered tanshinone IIA can efficiently inhibit AR transactivation,
block AR target genes expression in low concentration (0.1 μM), and then inhibit cell growth in
AR positive LNCaP cells. Our results suggest that tanshinone IIA could be a potential agent for the
treatment of prostate cancers.
Original language | American English |
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Pages (from-to) | 155-165 |
Journal | Journal of Chinese Medicine |
Volume | 25 |
Issue number | 2 |
DOIs | |
State | Published - 2014 |
Keywords
- LNCaP cells
- Tanshinone IIA
- androgen receptor
- prostate cancer