Targeting a miRNA–mRNA Regulatory Network to Overcome Radioresistance in Head and Neck Cancer: Identification of I-OMe-AG-538 via Transcriptome-Guided Drug Repurposing

Ann-Joy Cheng; Guo-Rung You; Joseph T. Chang; Hung-Han Huang; Eric Yi-Liang Shen; Yin-Ju Chen; Yen-Liang Li

doi:10.21203/rs.3.rs-8888021/v1

Targeting a miRNA–mRNA Regulatory Network to Overcome Radioresistance in Head and Neck Cancer: Identification of I-OMe-AG-538 via Transcriptome-Guided Drug Repurposing

Ann-Joy Cheng
, Guo-Rung You
, Joseph T. Chang
, Hung-Han Huang
, Eric Yi-Liang Shen
, Yin-Ju Chen
, Yen-Liang Li

Research output: Contribution to journal › Journal Article › peer-review

Original language	American English
Journal	Cell Death Discovery
DOIs	https://doi.org/10.21203/rs.3.rs-8888021/v1
State	Submitted - 18 03 2026

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.21203/rs.3.rs-8888021/v1

Cite this

@article{62955ce0616749de96dfac9b15ad4589,

title = "Targeting a miRNA{\textendash}mRNA Regulatory Network to Overcome Radioresistance in Head and Neck Cancer: Identification of I-OMe-AG-538 via Transcriptome-Guided Drug Repurposing",

author = "Ann-Joy Cheng and Guo-Rung You and Chang, \{Joseph T.\} and Hung-Han Huang and Shen, \{Eric Yi-Liang\} and Yin-Ju Chen and Yen-Liang Li",

year = "2026",

month = mar,

day = "18",

doi = "10.21203/rs.3.rs-8888021/v1",

language = "American English",

journal = "Cell Death Discovery",

issn = "2058-7716",

publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Targeting a miRNA–mRNA Regulatory Network to Overcome Radioresistance in Head and Neck Cancer: Identification of I-OMe-AG-538 via Transcriptome-Guided Drug Repurposing

AU - Cheng, Ann-Joy

AU - You, Guo-Rung

AU - Chang, Joseph T.

AU - Huang, Hung-Han

AU - Shen, Eric Yi-Liang

AU - Chen, Yin-Ju

AU - Li, Yen-Liang

PY - 2026/3/18

Y1 - 2026/3/18

UR - https://doi.org/10.21203/rs.3.rs-8888021/v1

U2 - 10.21203/rs.3.rs-8888021/v1

DO - 10.21203/rs.3.rs-8888021/v1

M3 - Journal Article

SN - 2058-7716

JO - Cell Death Discovery

JF - Cell Death Discovery

ER -

Targeting a miRNA–mRNA Regulatory Network to Overcome Radioresistance in Head and Neck Cancer: Identification of I-OMe-AG-538 via Transcriptome-Guided Drug Repurposing

UN SDGs

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