Targeting glycans for immunotherapy of human cancers

Jung Tung Hung; Alice L. Yu

doi:10.1007/978-4-431-55939-9_11

Targeting glycans for immunotherapy of human cancers

Jung Tung Hung, Alice L. Yu^*

^*Corresponding author for this work

Graduate Institute of Biomedical Sciences

Chang Gung Memorial Hospital

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Surface carbohydrate-containing molecules, such as glycoproteins and glycolipids, have been shown to play crucial regulatory roles in the normal physiological process as well as in pathological conditions including tumor progression. Those glycans which are overexpressed on the surface of tumor cells, but not detected or only weakly expressed in some limited normal tissues, are designated as tumor-associated carbohydrate antigens (TACAs). These TACAs may serve as potential targets for immunotherapy. The biological functions of TACAs and therapeutic strategies against TACAs will be addressed in this review.

Original language	English
Title of host publication	Glycosignals in Cancer
Subtitle of host publication	Mechanisms of Malignant Phenotypes
Publisher	Springer Japan
Pages	197-219
Number of pages	23
ISBN (Electronic)	9784431559399
ISBN (Print)	9784431559375
DOIs	https://doi.org/10.1007/978-4-431-55939-9_11
State	Published - 01 01 2016

Bibliographical note

Publisher Copyright:
© Springer Japan 2016.

Keywords

Angiogenesis
Cancer immunotherapy
Gd2
Globo h
Gm2
Immune checkpoints
Sialyl-tn

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-4-431-55939-9_11

Cite this

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Targeting glycans for immunotherapy of human cancers

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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