Telomerase activity in rat liver allografts

Shigeru Goto; Yu Chun Lin; Chia Yun Lai; Chuan Mo Lee; Tair Long Pan; Roger Lord; Kuei Chen Chiang; Hui Peng Tseng; Chen Lung Lin; Yu Fan Cheng; Hirotaka Yokoyama; Seigo Kitano; Chao Long Chen

doi:10.1097/00007890-200003150-00062

Telomerase activity in rat liver allografts

Shigeru Goto, Yu Chun Lin, Chia Yun Lai, Chuan Mo Lee, Tair Long Pan, Roger Lord, Kuei Chen Chiang, Hui Peng Tseng, Chen Lung Lin, Yu Fan Cheng, Hirotaka Yokoyama, Seigo Kitano, Chao Long Chen^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

5 Scopus citations

Abstract

Background. Telomerase activity in grafts may be involved in the alteration of cellular senescence after transplantation or its relevant immunological events. Methods. At the age of 20 weeks, donor livers harvested from DA (RT1^a) were orthotopically transplanted into PVG (RT1(c)) or LEW (RT1¹) rats. Rats having undergone orthotopic liver transplantation (OLT; DA-PVG) naturally overcome rejection, whereas all OLT (DA-LEW) rats die from acute rejection within 14 days. Telomerase activity in liver allografts was measured at various intervals post OLT. Results. At day 7 when the most severe rejection episode was observed in OLT (DA-LEW) and OLT (DA, PVG), the telomerase activity was significantly higher than in syngeneic OLT (DA-DA) rats, in which no rejection occurred. Telomerase activity in tolerogenic OLT (DA-PVG) livers remained elevated for at least 2 months. Conclusion. These results suggest that telomerase activity in allogeneic OLT livers may reflect regenerating hepatocytes or activation of lymphocytes and/or hematopoietic stem cells associated with rejection or tolerance.

Original language	English
Pages (from-to)	1013-1015
Number of pages	3
Journal	Transplantation
Volume	69
Issue number	5
DOIs	https://doi.org/10.1097/00007890-200003150-00062
State	Published - 15 03 2000
Externally published	Yes

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@article{f60b54ebc57548cbb20f3f7cadd85d7a,

title = "Telomerase activity in rat liver allografts",

abstract = "Background. Telomerase activity in grafts may be involved in the alteration of cellular senescence after transplantation or its relevant immunological events. Methods. At the age of 20 weeks, donor livers harvested from DA (RT1a) were orthotopically transplanted into PVG (RT1(c)) or LEW (RT11) rats. Rats having undergone orthotopic liver transplantation (OLT; DA-PVG) naturally overcome rejection, whereas all OLT (DA-LEW) rats die from acute rejection within 14 days. Telomerase activity in liver allografts was measured at various intervals post OLT. Results. At day 7 when the most severe rejection episode was observed in OLT (DA-LEW) and OLT (DA, PVG), the telomerase activity was significantly higher than in syngeneic OLT (DA-DA) rats, in which no rejection occurred. Telomerase activity in tolerogenic OLT (DA-PVG) livers remained elevated for at least 2 months. Conclusion. These results suggest that telomerase activity in allogeneic OLT livers may reflect regenerating hepatocytes or activation of lymphocytes and/or hematopoietic stem cells associated with rejection or tolerance.",

author = "Shigeru Goto and Lin, {Yu Chun} and Lai, {Chia Yun} and Lee, {Chuan Mo} and Pan, {Tair Long} and Roger Lord and Chiang, {Kuei Chen} and Tseng, {Hui Peng} and Lin, {Chen Lung} and Cheng, {Yu Fan} and Hirotaka Yokoyama and Seigo Kitano and Chen, {Chao Long}",

year = "2000",

month = mar,

day = "15",

doi = "10.1097/00007890-200003150-00062",

language = "英语",

volume = "69",

pages = "1013--1015",

journal = "Transplantation",

issn = "0041-1337",

publisher = "Lippincott Williams and Wilkins",

number = "5",

}

TY - JOUR

T1 - Telomerase activity in rat liver allografts

AU - Goto, Shigeru

AU - Lin, Yu Chun

AU - Lai, Chia Yun

AU - Lee, Chuan Mo

AU - Pan, Tair Long

AU - Lord, Roger

AU - Chiang, Kuei Chen

AU - Tseng, Hui Peng

AU - Lin, Chen Lung

AU - Cheng, Yu Fan

AU - Yokoyama, Hirotaka

AU - Kitano, Seigo

AU - Chen, Chao Long

PY - 2000/3/15

Y1 - 2000/3/15

N2 - Background. Telomerase activity in grafts may be involved in the alteration of cellular senescence after transplantation or its relevant immunological events. Methods. At the age of 20 weeks, donor livers harvested from DA (RT1a) were orthotopically transplanted into PVG (RT1(c)) or LEW (RT11) rats. Rats having undergone orthotopic liver transplantation (OLT; DA-PVG) naturally overcome rejection, whereas all OLT (DA-LEW) rats die from acute rejection within 14 days. Telomerase activity in liver allografts was measured at various intervals post OLT. Results. At day 7 when the most severe rejection episode was observed in OLT (DA-LEW) and OLT (DA, PVG), the telomerase activity was significantly higher than in syngeneic OLT (DA-DA) rats, in which no rejection occurred. Telomerase activity in tolerogenic OLT (DA-PVG) livers remained elevated for at least 2 months. Conclusion. These results suggest that telomerase activity in allogeneic OLT livers may reflect regenerating hepatocytes or activation of lymphocytes and/or hematopoietic stem cells associated with rejection or tolerance.

AB - Background. Telomerase activity in grafts may be involved in the alteration of cellular senescence after transplantation or its relevant immunological events. Methods. At the age of 20 weeks, donor livers harvested from DA (RT1a) were orthotopically transplanted into PVG (RT1(c)) or LEW (RT11) rats. Rats having undergone orthotopic liver transplantation (OLT; DA-PVG) naturally overcome rejection, whereas all OLT (DA-LEW) rats die from acute rejection within 14 days. Telomerase activity in liver allografts was measured at various intervals post OLT. Results. At day 7 when the most severe rejection episode was observed in OLT (DA-LEW) and OLT (DA, PVG), the telomerase activity was significantly higher than in syngeneic OLT (DA-DA) rats, in which no rejection occurred. Telomerase activity in tolerogenic OLT (DA-PVG) livers remained elevated for at least 2 months. Conclusion. These results suggest that telomerase activity in allogeneic OLT livers may reflect regenerating hepatocytes or activation of lymphocytes and/or hematopoietic stem cells associated with rejection or tolerance.

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U2 - 10.1097/00007890-200003150-00062

DO - 10.1097/00007890-200003150-00062

M3 - 文章

C2 - 10755570

AN - SCOPUS:0034654098

SN - 0041-1337

VL - 69

SP - 1013

EP - 1015

JO - Transplantation

JF - Transplantation

IS - 5

ER -

Telomerase activity in rat liver allografts

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