The 3-D imaging guidance system for the ultrasound treatment system on animal with Parkinson's disease

Jiann Der Lee*, Yi Hsuan Chu, Yao Y. Shieh, Hao Li Liu, Kun Ju Lin

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

This paper presents a prototype system for using high-intensity focused-ultrasound (HIFU) to treat the PD mouse under the designed stereotactic guidance. More specifically, the proposed system utilizes stereotactic guidance in concert with the technique of multi-modality SPECT/MRI registration. It comprises two key components: an automatic atlas-based SPECT/MR image registration module and a stereotactic positioning module. The reason for using SPECT/MR image registration here is because that imaging of dopamine transporters using 99mTc-TRODA-1 has been successfully applied to mice for the purpose of diagnosis of Parkinson's disease. From the experimental results, the proposed automatic image registration module proves to have comparable performance to that derived from manual drawing by experts. In general, the stereotactic positioning module achieved a positioning accuracy to within 2mm on the average, which is acceptable for the purpose of HIFU treatment.

Original languageEnglish
Title of host publicationISOB 2011 - Proceedings of the 1st International Symposium on Bioengineering
Pages120-127
Number of pages8
DOIs
StatePublished - 2011
Event1st International Symposium on Bioengineering, ISOB 2011 - Singapore, Singapore
Duration: 19 01 201119 01 2011

Publication series

NameISOB 2011 - Proceedings of the 1st International Symposium ISOB 2011 - Proceedings of the 1st International Symposium on Bioengineering

Conference

Conference1st International Symposium on Bioengineering, ISOB 2011
Country/TerritorySingapore
CitySingapore
Period19/01/1119/01/11

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