Abstract
Adhesion G protein-coupled receptors (aGPCRs) constitute the second largest GPCR subfamily. GPR56/ADGRG1 is a member of the ADGRG subgroup of aGPCRs. Although GPR56 is best known for its pivotal role in the cerebral cortical development, it is also important for tumor progression. Numerous studies have revealed that GPR56 is expressed in various cancer types with a role in cancer cell adhesion, migration and metastasis. In a recent study, we found that the immobilized GPR56-specific CG4 antibody enhanced IL-6 production and migration ability of melanoma cells. In this review, we will summarize the current understanding of GPR56 function and discuss the activation and signaling mechanisms of GPR56 in melanoma cells.
| Original language | English |
|---|---|
| Article number | 304 |
| Journal | Frontiers in Oncology |
| Volume | 8 |
| Issue number | AUG |
| DOIs | |
| State | Published - 08 08 2018 |
Bibliographical note
Publisher Copyright:© 2018 Huang and Lin.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Adhesion GPCR
- GPR56
- Melanoma
- Signaling pathways
- Tumor progression
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