The application of nanogenerators and piezoelectricity in osteogenesis

Fu Cheng Kao, Ping Yeh Chiu, Tsung Ting Tsai, Zong Hong Lin*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations

Abstract

Bone is a complex organ possessing both physicomechanical and bioelectrochemical properties. In the view of Wolff’s Law, bone can respond to mechanical loading and is subsequently reinforced in the areas of stress. Piezoelectricity is one of several mechanical responses of the bone matrix that allows osteocytes, osteoblasts, osteoclasts, and osteoprogenitors to react to changes in their environment. The present review details how osteocytes convert external mechanical stimuli into internal bioelectrical signals and the induction of intercellular cytokines from the standpoint of piezoelectricity. In addition, this review introduces piezoelectric and triboelectric materials used as self-powered electrical generators to promote osteogenic proliferation and differentiation due to their electromechanical properties, which could promote the development of promising applications in tissue engineering and bone regeneration.

Original languageEnglish
Pages (from-to)1103-1117
Number of pages15
JournalScience and Technology of Advanced Materials
Volume20
Issue number1
DOIs
StatePublished - 31 12 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019, © 2019 The Author(s). Published by National Institute for Materials Science in partnership with Taylor & Francis Group.

Keywords

  • 102 Porous / Nanoporous / Nanostructured materials
  • 202 Dielectrics / Piezoelectrics / Insulators
  • Osteogenesis
  • bone remodeling
  • nanogenerator
  • piezoelectricity

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