The association among antioxidant enzymes, autoantibodies, and disease severity score in systemic lupus erythematosus: Comparison of neuropsychiatric and nonneuropsychiatric groups

Yu Jih Su, Tien Tsai Cheng, Chung Jen Chen, Wen Chan Chiu, Wen Neng Chang, Nai Wen Tsai, Chia Te Kung, Wei Che Lin, Chih Cheng Huang, Ya Ting Chang, Chih Min Su, Yi Fang Chiang, Ben Chung Cheng, Cheng Hsien Lu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

6 Scopus citations

Abstract

Background. Antioxidative capacity plays an important role in the severity of systemic lupus erythematosus (SLE), which is characterized by autoantibodies. This study aimed to determine the relationship among autoantibody titers, antioxidative stress reserve, and severity of SLE. Methods. The autoantibody titers, clinical markers, antioxidant enzyme levels, and disease activity index (SLEDAI-2k) of 32 SLE patients and 16 healthy controls were compared. We also compared both the neuropsychiatric (NPSLE) and nonneuropsychiatric (non-NPSLE) groups. Results. Superoxide dismutase in red blood cells was significantly lower in the SLE than in the control group. CRP levels are significant higher in SLE patients than in control group (P = 0.034). Among the autoantibodies, anti-U1RNP P = 0.008, a-Sm P = 0.027, and anti-ribosomal p P = 0.028 significantly negatively correlated with glutathione levels. There has no significant correlation between SLE disease activity indexes (SLEDAI) and levels of C3, C4, and antioxidant enzymes. Conclusions. Erythrocyte superoxide dismutase is significantly lower in both NPSLE and non-NPSLE groups. SLE patients have both higher CRP and autoantibodies level and decreased superoxide dismutase level than the healthy control group.

Original languageEnglish
Article number137231
JournalBioMed Research International
Volume2014
DOIs
StatePublished - 2014

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