The association between caustic ingestion and psychiatric comorbidity based on 396 adults within 20 years

Yu Jhou Chen, Chen June Seak, Chien Cheng Chen, Tsung Hsing Chen, Shih Ching Kang, Chip Jin Ng, Chao Wei Lee, Ming Yao Su, Hsin Chih Huang, Chun Hsiang Ooyang, Sen Yung Hsieh, Hao Tsai Cheng*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

5 Scopus citations


Purpose: High prevalence of psychiatric comorbidities (PCs) has been widely documented in caustic substance ingestion cases. However, their effect on the clinical features and prognostic outcomes remains unclear due to the paucity of discussion. We report on detailed clinical courses with long-term multifaceted outcomes and review the association between caustic ingestion and each specific PC. Patients and Methods: The retrospective chart review included 396 adults (median follow-up, 16.6 months) with and 377 without (control group) PCs treated between 1999 and 2018 at Chang Gung Memorial Hospital. All PCs were diagnosed/confirmed by psy-chiatrists through face-to-face interviews. Results: The PCs predicted serious esophagogastroduodenoscopy grading, higher rates of admission/surgery/intensive care unit stay, increments of systemic/gastrointestinal complica-tions, and poorer 5-year overall survival rates. The poor survival among patients with PCs was highly consistent with their baseline characteristics. Significantly advanced age, more non-PCs, alcoholism, illicit drug abuse, and baseline unhealthy status resulted in statistically higher risks of severe complications and limited recovery. Conclusion: PCs changed clinical patterns and had critical roles in the survival outcomes of caustic injury victims. Clinical awareness achieves benefit by limiting injuries in mild cases or allowing emergent interventions in severe cases. Future studies based on worldwide populations are essential for realizing geographic differences.

Original languageEnglish
Pages (from-to)1815-1824
Number of pages10
JournalRisk Management and Healthcare Policy
StatePublished - 2020

Bibliographical note

Publisher Copyright:
© 2020 Chen et al.


  • Caustic
  • Complications
  • Corrosive
  • Endoscopy
  • Long-term survival
  • Psychiatric


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