The association between plasma angiopoietin-like protein 4, glucose and lipid metabolism during pregnancy, placental function, and risk of delivering large-for-gestational-age neonates

I. Weng Yen, Shin Yu Lin, Ming Wei Lin, Chien Nan Lee, Chun Heng Kuo, Szu Chieh Chen, Yi Yun Tai, Ching Hua Kuo, Han Chun Kuo, Heng Huei Lin, Hsien Chia Juan, Chia Hung Lin, Kang Chih Fan, Chih Yuan Wang, Hung Yuan Li*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

Abstract

Background: Large-for-gestational-age (LGA) neonates have increased risk of adverse pregnancy outcomes and adult metabolic diseases. We aimed to investigate the relationship between plasma angiopoietin-like protein 4 (ANGPTL4), a protein involved in lipid and glucose metabolism during pregnancy, placental function, growth factors, and the risk of LGA. Methods: We conducted a prospective cohort study and recruited women with singleton pregnancies at the National Taiwan University Hospital between 2013 and 2018. First trimester maternal plasma ANGPTL4 concentrations were measured. Results: Among 353 pregnant women recruited, the LGA group had higher first trimester plasma ANGPTL4 concentrations than the appropriate-for-gestational-age group. Plasma ANGPTL4 was associated with hemoglobin A1c, post-load plasma glucose, plasma triglyceride, plasma free fatty acid concentrations, plasma growth hormone variant (GH-V), and birth weight, but was not associated with cord blood growth factors. After adjusting for age, body mass index, hemoglobin A1c, and plasma triglyceride concentrations, plasma ANGPTL4 concentrations were significantly associated with LGA risk, and its predictive performance, as measured by the area under the receiver operating characteristic curve, outperformed traditional risk factors for LGA. Conclusions: Plasma ANGPTL4 is associated with glucose and lipid metabolism during pregnancy, plasma GH-V, and birth weight, and is an early biomarker for predicting the risk of LGA.

Original languageEnglish
Article number117775
Pages (from-to)117775
JournalClinica Chimica Acta
Volume554
DOIs
StatePublished - 01 02 2024
Externally publishedYes

Bibliographical note

Copyright © 2024 Elsevier B.V. All rights reserved.

Keywords

  • Angiopoietin-like protein 4
  • ANGPTL4
  • Birth weight
  • Large-for-gestational-age
  • Pregnancy
  • Prospective Studies
  • Humans
  • Glycated Hemoglobin
  • Lipid Metabolism
  • Triglycerides
  • Glucose
  • Gestational Age
  • Birth Weight
  • Placenta
  • Angiopoietin-Like Protein 4
  • Adult
  • Female
  • Infant, Newborn
  • Pregnancy Outcome

Fingerprint

Dive into the research topics of 'The association between plasma angiopoietin-like protein 4, glucose and lipid metabolism during pregnancy, placental function, and risk of delivering large-for-gestational-age neonates'. Together they form a unique fingerprint.

Cite this