The association between polyomavirus BK strains and BKV viruria in liver transplant recipients

Robert Y.L. Wang; Yi Jung Li; Wei Chen Lee; Hsin Hsu Wu; Chan Yu Lin; Cheng Chia Lee; Yung Chang Chen; Cheng Chieh Hung; Chih Wei Yang; Ya Chung Tian

doi:10.1038/srep28491

The association between polyomavirus BK strains and BKV viruria in liver transplant recipients

Robert Y.L. Wang, Yi Jung Li, Wei Chen Lee, Hsin Hsu Wu, Chan Yu Lin, Cheng Chia Lee, Yung Chang Chen, Cheng Chieh Hung, Chih Wei Yang, Ya Chung Tian^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

6 Scopus citations

Abstract

BK virus (BKV) is a polyomavirus that cause of allograft dysfunction among kidney transplant recipients. The role of BKV infection in non-renal solid organ transplant recipients is not well understood neither for the relationship between various BKV strains with occurrence of BKV viral viruria. This study aimed to understand the prevalence of BKV infection and identified of BKV various strains in the urine of liver transplant recipients. There was not significant difference of renal outcome between high BKV viruria and low BKV viruria in the liver transplant recipients. The WW-non-coding control region (NCCR) BKV detected in urine was associated with higher urinary BKV load, whereas the Dunlop-NCCR BKV was detected in the urine of low urinary BKV load. An in vitro cultivation system demonstrated that WW-BKV strain exhibiting the higher viral DNA replication efficiency and higher BKV load. Altogether, this is the first study to demonstrate the impact of BKV strains on the occurrence of BK viruria in the liver transplant recipients.

Original language	English
Article number	28491
Journal	Scientific Reports
Volume	6
DOIs	https://doi.org/10.1038/srep28491
State	Published - 24 06 2016

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title = "The association between polyomavirus BK strains and BKV viruria in liver transplant recipients",

abstract = "BK virus (BKV) is a polyomavirus that cause of allograft dysfunction among kidney transplant recipients. The role of BKV infection in non-renal solid organ transplant recipients is not well understood neither for the relationship between various BKV strains with occurrence of BKV viral viruria. This study aimed to understand the prevalence of BKV infection and identified of BKV various strains in the urine of liver transplant recipients. There was not significant difference of renal outcome between high BKV viruria and low BKV viruria in the liver transplant recipients. The WW-non-coding control region (NCCR) BKV detected in urine was associated with higher urinary BKV load, whereas the Dunlop-NCCR BKV was detected in the urine of low urinary BKV load. An in vitro cultivation system demonstrated that WW-BKV strain exhibiting the higher viral DNA replication efficiency and higher BKV load. Altogether, this is the first study to demonstrate the impact of BKV strains on the occurrence of BK viruria in the liver transplant recipients.",

author = "Wang, {Robert Y.L.} and Li, {Yi Jung} and Lee, {Wei Chen} and Wu, {Hsin Hsu} and Lin, {Chan Yu} and Lee, {Cheng Chia} and Chen, {Yung Chang} and Hung, {Cheng Chieh} and Yang, {Chih Wei} and Tian, {Ya Chung}",

year = "2016",

month = jun,

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doi = "10.1038/srep28491",

language = "英语",

volume = "6",

journal = "Scientific Reports",

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T1 - The association between polyomavirus BK strains and BKV viruria in liver transplant recipients

AU - Wang, Robert Y.L.

AU - Li, Yi Jung

AU - Lee, Wei Chen

AU - Wu, Hsin Hsu

AU - Lin, Chan Yu

AU - Lee, Cheng Chia

AU - Chen, Yung Chang

AU - Hung, Cheng Chieh

AU - Yang, Chih Wei

AU - Tian, Ya Chung

PY - 2016/6/24

Y1 - 2016/6/24

N2 - BK virus (BKV) is a polyomavirus that cause of allograft dysfunction among kidney transplant recipients. The role of BKV infection in non-renal solid organ transplant recipients is not well understood neither for the relationship between various BKV strains with occurrence of BKV viral viruria. This study aimed to understand the prevalence of BKV infection and identified of BKV various strains in the urine of liver transplant recipients. There was not significant difference of renal outcome between high BKV viruria and low BKV viruria in the liver transplant recipients. The WW-non-coding control region (NCCR) BKV detected in urine was associated with higher urinary BKV load, whereas the Dunlop-NCCR BKV was detected in the urine of low urinary BKV load. An in vitro cultivation system demonstrated that WW-BKV strain exhibiting the higher viral DNA replication efficiency and higher BKV load. Altogether, this is the first study to demonstrate the impact of BKV strains on the occurrence of BK viruria in the liver transplant recipients.

AB - BK virus (BKV) is a polyomavirus that cause of allograft dysfunction among kidney transplant recipients. The role of BKV infection in non-renal solid organ transplant recipients is not well understood neither for the relationship between various BKV strains with occurrence of BKV viral viruria. This study aimed to understand the prevalence of BKV infection and identified of BKV various strains in the urine of liver transplant recipients. There was not significant difference of renal outcome between high BKV viruria and low BKV viruria in the liver transplant recipients. The WW-non-coding control region (NCCR) BKV detected in urine was associated with higher urinary BKV load, whereas the Dunlop-NCCR BKV was detected in the urine of low urinary BKV load. An in vitro cultivation system demonstrated that WW-BKV strain exhibiting the higher viral DNA replication efficiency and higher BKV load. Altogether, this is the first study to demonstrate the impact of BKV strains on the occurrence of BK viruria in the liver transplant recipients.

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DO - 10.1038/srep28491

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SN - 2045-2322

VL - 6

JO - Scientific Reports

JF - Scientific Reports

M1 - 28491

ER -

The association between polyomavirus BK strains and BKV viruria in liver transplant recipients

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