The association of statin therapy and high-sensitivity C‐reactive protein level for predicting clinical outcome in acute non-cardioembolic ischemic stroke

Nai Wen Tsai, Lian Hui Lee, Chi Ren Huang, Wen Neng Chang, Shang Der Chen, Hung Chen Wang, Yu Jun Lin, Wei Che Lin, Yi Fang Chiang, Tsu Kung Lin, Ben Chung Cheng, Yu Jih Su, Chia Te Kung, Shu Hua Hung, Hsueh Wen Chang, Cheng Hsien Lu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

25 Scopus citations

Abstract

Background Statins reportedly have anti-inflammatory effects aside from their cholesterol-lowering effect. We investigated the effects of statins on serum hs-CRP level and clinical outcome of acute ischemic stroke (IS) patients. Methods This prospective cohort study consequently evaluated patients with acute IS in a single medical center. Serum hs-CRP levels were measured at different time points (within 48 h and 30 days post-stroke). The patients’ clinical and laboratory data on admission were analyzed. Results Total 100 patients with acute IS were divided in the statin group (n = 50) and the non-statin group (n = 50). Serum hs-CRP level was similar in the 2 groups within 48 h after acute IS, but was significantly lower in the statin group on Day 30 compared to the non-statin group (p < 0.05). The statin group also had favorable 3-month outcome compared to the non-statin group (p < 0.05). After adjustments for covariance using stepwise logistic regression, only NIHSS on admission (OR = 1.38, 95% CI = 1.06–1.80; p = 0.02) and hs-CRP in the acute phase (OR = 1.74, 95% CI = 1.30–2.33; p = 0.001) were significantly and independently predictive of 3-month outcome. Conclusion Statin therapy reduces serum hs-CRP level and may be associated with favorable 3-month outcome in patients after acute IS.

Original languageEnglish
Pages (from-to)1861-1865
Number of pages5
JournalClinica Chimica Acta
Volume413
Issue number23-24
DOIs
StatePublished - 20 11 2012

Bibliographical note

Publisher Copyright:
© 2012

Keywords

  • Clinical outcome
  • High-sensitivity C-reactive protein
  • Ischemic stroke
  • Statin

Fingerprint

Dive into the research topics of 'The association of statin therapy and high-sensitivity C‐reactive protein level for predicting clinical outcome in acute non-cardioembolic ischemic stroke'. Together they form a unique fingerprint.

Cite this