TY - JOUR
T1 - The associations between helicobacter pylori infection, serum Vitamin D, and metabolic syndrome
T2 - A community-based study
AU - Chen, Li Wei
AU - Chien, Chih Yi
AU - Hsieh, Chia Wen
AU - Chang, Liang Che
AU - Huang, Mei Huei
AU - Huang, Wen Yuan
AU - Kuo, Sheng Fong
AU - Chien, Cheng Hung
AU - Lin, Chih Lang
AU - Chien, Rong Nan
N1 - Publisher Copyright:
Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2016
Y1 - 2016
N2 - The associations between Helicobacter pylori infection, serum vitamin D level, and metabolic syndrome (MS) are controversial. The present community-based study aimed to investigate the effect of H pylori infection and serum vitamin D deficiency on MS development. Individuals from the northeastern region of Taiwan were enrolled in a community-based study from March, 2014 to August, 2015. All participants completed a demographic survey and underwent the urea breath test (UBT) to detect H pylori infection as well as blood tests to determine levels of vitamin D, adiponectin, leptin, and high-sensitivity C-reactive protein. The ATP III criteria for MS were used in this study. A total of 792 men and 1321 women were enrolled. The mean age was 56.413.0 years. After adjusting for age and sex, the estimated odds of MS development for a UBT-positive subject were 1.503 (95% confidence interval [CI]: 1.206-1.872, P<0.001) when compared to a UBT-negative subject. For participants with vitamin D deficiency (<20 ng/mL), the odds of MS development were 1.423 (95% CI: 1.029-1.967, P=0.033) when compared to those with sufficient vitamin D level (>30 ng/mL). For participants with both H pylori infection and vitamin D deficiency, the odds of MS development were 2.140 (95% CI: 1.348-3.398, P=0.001) when compared to subjects without H pylori infection and with sufficient vitamin D levels. H pylori infection and vitamin D deficiency could be predictors of MS. For individuals with both H pylori infection and vitamin D deficiency, the odds of MS development were 2.140 when compared to individuals without H pylori infection and with sufficient vitamin D levels.
AB - The associations between Helicobacter pylori infection, serum vitamin D level, and metabolic syndrome (MS) are controversial. The present community-based study aimed to investigate the effect of H pylori infection and serum vitamin D deficiency on MS development. Individuals from the northeastern region of Taiwan were enrolled in a community-based study from March, 2014 to August, 2015. All participants completed a demographic survey and underwent the urea breath test (UBT) to detect H pylori infection as well as blood tests to determine levels of vitamin D, adiponectin, leptin, and high-sensitivity C-reactive protein. The ATP III criteria for MS were used in this study. A total of 792 men and 1321 women were enrolled. The mean age was 56.413.0 years. After adjusting for age and sex, the estimated odds of MS development for a UBT-positive subject were 1.503 (95% confidence interval [CI]: 1.206-1.872, P<0.001) when compared to a UBT-negative subject. For participants with vitamin D deficiency (<20 ng/mL), the odds of MS development were 1.423 (95% CI: 1.029-1.967, P=0.033) when compared to those with sufficient vitamin D level (>30 ng/mL). For participants with both H pylori infection and vitamin D deficiency, the odds of MS development were 2.140 (95% CI: 1.348-3.398, P=0.001) when compared to subjects without H pylori infection and with sufficient vitamin D levels. H pylori infection and vitamin D deficiency could be predictors of MS. For individuals with both H pylori infection and vitamin D deficiency, the odds of MS development were 2.140 when compared to individuals without H pylori infection and with sufficient vitamin D levels.
UR - http://www.scopus.com/inward/record.url?scp=84969900749&partnerID=8YFLogxK
U2 - 10.1097/MD.0000000000003616
DO - 10.1097/MD.0000000000003616
M3 - 文章
C2 - 27149497
AN - SCOPUS:84969900749
SN - 0025-7974
VL - 95
SP - e3616
JO - Medicine (United States)
JF - Medicine (United States)
IS - 18
ER -