TY - JOUR
T1 - The burden of asthma, hay fever and eczema in children in 25 countries
T2 - GAN Phase I study
AU - the Global Asthma Network Phase I Study Group
AU - Global Asthma Network Study Group
AU - Global Asthma Network Steering Group
AU - Global Asthma Network Principal Investigators
AU - García-Marcos, Luis
AU - Asher, M. Innes
AU - Pearce, Neil
AU - Ellwood, Eamon
AU - Bissell, Karen
AU - Chiang, Chen Yuan
AU - El Sony, Asma
AU - Ellwood, Philippa
AU - Marks, Guy B.
AU - Mortimer, Kevin
AU - Martínez-Torres, A. Elena
AU - Morales, Eva
AU - Perez-Fernandez, Virginia
AU - Robertson, Steven
AU - Rutter, Charlotte E.
AU - Silverwood, Richard J.
AU - Strachan, David P.
AU - Masekela, R.
AU - Badellino, H.
AU - Urrutia-Pereira, M.
AU - Ndikum, A. E.
AU - Mallol, J.
AU - Soto-Martínez, M. E.
AU - Cabrera Aguilar, A.
AU - Douros, K.
AU - Sosa Ferrari, S. M.
AU - Mohammad, S.
AU - Singh, M.
AU - Singh, V.
AU - Ghoshal, A. G.
AU - Sukumaran, T. U.
AU - Awasthi, S.
AU - Mahesh, P. A.
AU - Kabra, S. K.
AU - Salvi, S.
AU - Tavakol, M.
AU - Behniafard, N.
AU - Alomary, S. A.
AU - Bucaliu-Ismajli, I.
AU - Pajaziti, L.
AU - Gashi, V.
AU - Kurhasani, X.
AU - Gacaferri-Lumezi, B.
AU - Ahmetaj, L. N.
AU - Zhjeqi, V.
AU - Sanchez Coronel, M. G.
AU - Moreno Gardea, H. L.
AU - Ochoa-Lopez, G.
AU - García-Almaráz, R.
AU - Huang, J.
N1 - Publisher Copyright:
© The authors 2022.
PY - 2022/9/1
Y1 - 2022/9/1
N2 - Aims There have been no worldwide standardised surveys of prevalence and severity of asthma, rhinoconjunctivitis and eczema in school children for 15 years. The present study aims to provide this information. Methods Following the exact International Study of Asthma and Allergies in Childhood (ISAAC) methodology (cross-sectional questionnaire-based survey), Global Asthma Network (GAN) Phase I was carried out between 2015 and 2020 in many centres worldwide. Results The study included 157784 adolescents (13-14 years of age) in 63 centres in 25 countries and 101777 children (6-7 years of age) in 44 centres in 16 countries. The current prevalence of symptoms, respectively, was 11.0% and 9.1% for asthma, 13.3% and 7.7% for rhinoconjunctivitis and 6.4% and 5.9% for eczema. The prevalence of asthma ever was 10.5% and 7.6%, hay fever ever was 15.2% and 11.1% and eczema ever was 10.6% and 13.4%, respectively. Centres in low or lower middle gross national income countries (LICs or LMICs) had significantly lower prevalence of the three disease symptoms and diagnoses (except for hay fever). In children, the prevalence of asthma and rhinoconjunctivitis symptoms was higher in boys, while the reverse occurred among adolescents. For eczema, while the prevalence among female adolescents was double that of males, there was no sex difference among children. Centre accounted for non-negligible variability in all disease symptoms (10-20%). Conclusion The burdens of asthma, rhinoconjunctivitis and eczema vary widely among the limited number of countries studied. Although symptom prevalence is lower in LICs and LMICs, it represents a considerable burden everywhere studied.
AB - Aims There have been no worldwide standardised surveys of prevalence and severity of asthma, rhinoconjunctivitis and eczema in school children for 15 years. The present study aims to provide this information. Methods Following the exact International Study of Asthma and Allergies in Childhood (ISAAC) methodology (cross-sectional questionnaire-based survey), Global Asthma Network (GAN) Phase I was carried out between 2015 and 2020 in many centres worldwide. Results The study included 157784 adolescents (13-14 years of age) in 63 centres in 25 countries and 101777 children (6-7 years of age) in 44 centres in 16 countries. The current prevalence of symptoms, respectively, was 11.0% and 9.1% for asthma, 13.3% and 7.7% for rhinoconjunctivitis and 6.4% and 5.9% for eczema. The prevalence of asthma ever was 10.5% and 7.6%, hay fever ever was 15.2% and 11.1% and eczema ever was 10.6% and 13.4%, respectively. Centres in low or lower middle gross national income countries (LICs or LMICs) had significantly lower prevalence of the three disease symptoms and diagnoses (except for hay fever). In children, the prevalence of asthma and rhinoconjunctivitis symptoms was higher in boys, while the reverse occurred among adolescents. For eczema, while the prevalence among female adolescents was double that of males, there was no sex difference among children. Centre accounted for non-negligible variability in all disease symptoms (10-20%). Conclusion The burdens of asthma, rhinoconjunctivitis and eczema vary widely among the limited number of countries studied. Although symptom prevalence is lower in LICs and LMICs, it represents a considerable burden everywhere studied.
UR - https://www.scopus.com/pages/publications/85138446829
U2 - 10.1183/13993003.02866-2021
DO - 10.1183/13993003.02866-2021
M3 - 文章
C2 - 35144987
AN - SCOPUS:85138446829
SN - 0903-1936
VL - 60
JO - European Respiratory Journal
JF - European Respiratory Journal
IS - 3
M1 - 2102866
ER -
SDG 3 Good Health and Well-being