The Cellular and Molecular Network of IL-4 and IL-13

Fernando O. Martinez Estrada*, Siamon Gordon

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Interleukin (IL)-4 and IL-13 control the phenotype of a variety of cells in health and disease. Their receptor system, signaling cascades, and functional properties have gained clarity in the past 30. years. In this article, we give an overview of the production, sensing, and effects of both cytokines concluding with a discussion of the therapeutic potential of IL-4 and IL-13 inhibition or supplementation in patients.

Original languageEnglish
Title of host publicationMolecular Immunology
PublisherElsevier Inc.
Number of pages6
ISBN (Print)9780080921525
StatePublished - 27 04 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ltd All rights reserved.


  • Allergy
  • Alternative activation
  • Biologics
  • Fibrosis
  • IL-13
  • IL-4
  • Mast cells
  • Signaling
  • Th2 cells


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