The Cellular and Molecular Network of IL-4 and IL-13

Fernando O. Martinez; Siamon Gordon

doi:10.1016/B978-0-12-824465-4.00168-X

The Cellular and Molecular Network of IL-4 and IL-13

Fernando O. Martinez
, Siamon Gordon

Division of Microbiology and Immunology

University of Surrey
University of Oxford

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

IL-4 and IL-13 are Th2 cytokines, primarily involved in the immune response to helminths, that control the phenotype of a variety of tissue cells in health and disease. This is opposed to the Th1 interferon response which is directed towards intracellular microorganisms. The IL-4 and IL-13 receptor system, signaling cascades and functional properties in different cell types have gained clarity in the past four decades. In this chapter we give an updated overview of the production, sensing and effects of both cytokines with emphasis on macrophages and functional consequences of the activation, concluding with a discussion of the advances in therapeutic options based on IL-4 receptor inhibition.

Original language	English
Title of host publication	Encyclopedia of Immunobiology
Publisher	Elsevier
Pages	V2:671-V2:680
ISBN (Electronic)	9780128244654
ISBN (Print)	9780123742797
DOIs	https://doi.org/10.1016/B978-0-12-824465-4.00168-X
State	Published - 01 01 2025

Bibliographical note

Publisher Copyright:
© 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

Keywords

Allergy
Fibrosis
IL-4, IL-13
Macrophage alternative activation
Mast cells
Signaling, Biologics
Th2 cells

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10.1016/B978-0-12-824465-4.00168-X

Cite this

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KW - Fibrosis

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KW - Mast cells

KW - Signaling, Biologics

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The Cellular and Molecular Network of IL-4 and IL-13

Abstract

Bibliographical note

Keywords

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