The Cellular and Molecular Network of IL-4 and IL-13

Fernando O. Martinez Estrada; Siamon Gordon

doi:10.1016/B978-0-12-374279-7.10012-8

The Cellular and Molecular Network of IL-4 and IL-13

Fernando O. Martinez Estrada^*
, Siamon Gordon

^*Corresponding author for this work

University of Oxford

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Interleukin (IL)-4 and IL-13 control the phenotype of a variety of cells in health and disease. Their receptor system, signaling cascades, and functional properties have gained clarity in the past 30. years. In this article, we give an overview of the production, sensing, and effects of both cytokines concluding with a discussion of the therapeutic potential of IL-4 and IL-13 inhibition or supplementation in patients.

Original language	English
Title of host publication	Molecular Immunology
Publisher	Elsevier Inc.
Pages	519-524
Number of pages	6
Volume	2
ISBN (Print)	9780080921525
DOIs	https://doi.org/10.1016/B978-0-12-374279-7.10012-8
State	Published - 27 04 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ltd All rights reserved.

Keywords

Allergy
Alternative activation
Biologics
Fibrosis
IL-13
IL-4
Mast cells
Signaling
Th2 cells

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10.1016/B978-0-12-374279-7.10012-8

Cite this

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KW - Allergy

KW - Alternative activation

KW - Biologics

KW - Fibrosis

KW - IL-13

KW - IL-4

KW - Mast cells

KW - Signaling

KW - Th2 cells

UR - https://www.scopus.com/pages/publications/85043294661

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DO - 10.1016/B978-0-12-374279-7.10012-8

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VL - 2

SP - 519

EP - 524

BT - Molecular Immunology

PB - Elsevier Inc.

ER -

The Cellular and Molecular Network of IL-4 and IL-13

Abstract

Bibliographical note

Keywords

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