The change in circulating tumor cells before and during concurrent chemoradiotherapy is associated with survival in patients with locally advanced head and neck cancer

Hung Ming Wang; Min Hsien Wu; Pei Hung Chang; Hung Chi Lin; Chun Da Liao; Sheng Min Wu; Tsung Min Hung; Chine Yu Lin; Tung Chieh Chang; Yen Tzu-Tsen; Jason Chia Hsun Hsieh

doi:10.1002/hed.25744

The change in circulating tumor cells before and during concurrent chemoradiotherapy is associated with survival in patients with locally advanced head and neck cancer

Hung Ming Wang
, Min Hsien Wu
, Pei Hung Chang
, Hung Chi Lin
, Chun Da Liao
, Sheng Min Wu
, Tsung Min Hung
, Chine Yu Lin
, Tung Chieh Chang
, Yen Tzu-Tsen
, Jason Chia Hsun Hsieh^*

^*Corresponding author for this work

Chang Gung University

Research output: Contribution to journal › Journal Article › peer-review

36 Scopus citations

Abstract

Background: This study aimed to evaluate the role of baseline circulating tumor cells (CTCs) before and during concurrent chemoradiotherapy and attempted to determine the impacts of CTCs on the outcomes in patients with head and neck squamous cell carcinoma. Methods: CTCs were detected using a negative selection strategy and flow cytometry protocol. Results: We observed a significant correlation between baseline CTCs and staging (P = 0.001). The CTC counts were significantly reduced within 2-4 weeks in 47 concurrent chemoradiotherapy responders (P < 0.001). Change of CTC counts correlates with progression-free survival (PFS, P = 0.01) and overall survival (OS, P = 0.01). CTC decline status was an independent prognostic factor in PFS (P = 0.03) and OS (P = 0.05) in multivariate analyses. Conclusion: In chemoradiotherapy responders, CTCs are significantly reduced. CTC decline within the first month indicates a longer PFS and OS, suggesting that the dynamics of CTCs could be more important than CTC number alone.

Original language	English
Pages (from-to)	2676-2687
Number of pages	12
Journal	Head and Neck
Volume	41
Issue number	8
DOIs	https://doi.org/10.1002/hed.25744
State	Published - 08 2019

Bibliographical note

Publisher Copyright:
© 2019 Wiley Periodicals, Inc.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cancer
circulating tumor cells
concurrent chemoradiotherapy
patients with cancer
survival

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10.1002/hed.25744

Cite this

Wang, H. M., Wu, M. H., Chang, P. H., Lin, H. C., Liao, C. D., Wu, S. M., Hung, T. M., Lin, C. Y., Chang, T. C., Tzu-Tsen, Y., & Hsieh, J. C. H. (2019). The change in circulating tumor cells before and during concurrent chemoradiotherapy is associated with survival in patients with locally advanced head and neck cancer. Head and Neck, 41(8), 2676-2687. https://doi.org/10.1002/hed.25744

@article{5c665e3aa6504626a47ad7b2b4374a93,

title = "The change in circulating tumor cells before and during concurrent chemoradiotherapy is associated with survival in patients with locally advanced head and neck cancer",

abstract = "Background: This study aimed to evaluate the role of baseline circulating tumor cells (CTCs) before and during concurrent chemoradiotherapy and attempted to determine the impacts of CTCs on the outcomes in patients with head and neck squamous cell carcinoma. Methods: CTCs were detected using a negative selection strategy and flow cytometry protocol. Results: We observed a significant correlation between baseline CTCs and staging (P = 0.001). The CTC counts were significantly reduced within 2-4 weeks in 47 concurrent chemoradiotherapy responders (P < 0.001). Change of CTC counts correlates with progression-free survival (PFS, P = 0.01) and overall survival (OS, P = 0.01). CTC decline status was an independent prognostic factor in PFS (P = 0.03) and OS (P = 0.05) in multivariate analyses. Conclusion: In chemoradiotherapy responders, CTCs are significantly reduced. CTC decline within the first month indicates a longer PFS and OS, suggesting that the dynamics of CTCs could be more important than CTC number alone.",

keywords = "cancer, circulating tumor cells, concurrent chemoradiotherapy, patients with cancer, survival",

author = "Wang, \{Hung Ming\} and Wu, \{Min Hsien\} and Chang, \{Pei Hung\} and Lin, \{Hung Chi\} and Liao, \{Chun Da\} and Wu, \{Sheng Min\} and Hung, \{Tsung Min\} and Lin, \{Chine Yu\} and Chang, \{Tung Chieh\} and Yen Tzu-Tsen and Hsieh, \{Jason Chia Hsun\}",

note = "Publisher Copyright: {\textcopyright} 2019 Wiley Periodicals, Inc.",

year = "2019",

month = aug,

doi = "10.1002/hed.25744",

language = "英语",

volume = "41",

pages = "2676--2687",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley \& Sons Inc.",

number = "8",

}

TY - JOUR

T1 - The change in circulating tumor cells before and during concurrent chemoradiotherapy is associated with survival in patients with locally advanced head and neck cancer

AU - Wang, Hung Ming

AU - Wu, Min Hsien

AU - Chang, Pei Hung

AU - Lin, Hung Chi

AU - Liao, Chun Da

AU - Wu, Sheng Min

AU - Hung, Tsung Min

AU - Lin, Chine Yu

AU - Chang, Tung Chieh

AU - Tzu-Tsen, Yen

AU - Hsieh, Jason Chia Hsun

PY - 2019/8

Y1 - 2019/8

N2 - Background: This study aimed to evaluate the role of baseline circulating tumor cells (CTCs) before and during concurrent chemoradiotherapy and attempted to determine the impacts of CTCs on the outcomes in patients with head and neck squamous cell carcinoma. Methods: CTCs were detected using a negative selection strategy and flow cytometry protocol. Results: We observed a significant correlation between baseline CTCs and staging (P = 0.001). The CTC counts were significantly reduced within 2-4 weeks in 47 concurrent chemoradiotherapy responders (P < 0.001). Change of CTC counts correlates with progression-free survival (PFS, P = 0.01) and overall survival (OS, P = 0.01). CTC decline status was an independent prognostic factor in PFS (P = 0.03) and OS (P = 0.05) in multivariate analyses. Conclusion: In chemoradiotherapy responders, CTCs are significantly reduced. CTC decline within the first month indicates a longer PFS and OS, suggesting that the dynamics of CTCs could be more important than CTC number alone.

AB - Background: This study aimed to evaluate the role of baseline circulating tumor cells (CTCs) before and during concurrent chemoradiotherapy and attempted to determine the impacts of CTCs on the outcomes in patients with head and neck squamous cell carcinoma. Methods: CTCs were detected using a negative selection strategy and flow cytometry protocol. Results: We observed a significant correlation between baseline CTCs and staging (P = 0.001). The CTC counts were significantly reduced within 2-4 weeks in 47 concurrent chemoradiotherapy responders (P < 0.001). Change of CTC counts correlates with progression-free survival (PFS, P = 0.01) and overall survival (OS, P = 0.01). CTC decline status was an independent prognostic factor in PFS (P = 0.03) and OS (P = 0.05) in multivariate analyses. Conclusion: In chemoradiotherapy responders, CTCs are significantly reduced. CTC decline within the first month indicates a longer PFS and OS, suggesting that the dynamics of CTCs could be more important than CTC number alone.

KW - cancer

KW - circulating tumor cells

KW - concurrent chemoradiotherapy

KW - patients with cancer

KW - survival

UR - https://www.scopus.com/pages/publications/85063258896

U2 - 10.1002/hed.25744

DO - 10.1002/hed.25744

M3 - 文章

C2 - 30903634

AN - SCOPUS:85063258896

SN - 1043-3074

VL - 41

SP - 2676

EP - 2687

JO - Head and Neck

JF - Head and Neck

IS - 8

ER -

The change in circulating tumor cells before and during concurrent chemoradiotherapy is associated with survival in patients with locally advanced head and neck cancer

Abstract

Bibliographical note

UN SDGs

Keywords

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