TY - JOUR
T1 - The Chemically Highly Diversified Metabolites from the Red Sea Marine Sponge Spongia sp.
AU - Tai, Chi Jen
AU - Ahmed, Atallah F.
AU - Chao, Chih Hua
AU - Yen, Chia Hung
AU - Hwang, Tsong Long
AU - Chang, Fang Rong
AU - Huang, Yusheng M.
AU - Sheu, Jyh Horng
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/4
Y1 - 2022/4
N2 - A polyoxygenated and halogenated labdane, spongianol (1); a polyoxygenated steroid, 3β,5α,9α-trihydroxy-24S-ethylcholest-7-en-6-one (2); a rare seven-membered lactone B ring, (22E,24S)-ergosta-7,22-dien-3β,5α-diol-6,5-olide (3); and an α,β-unsaturated fatty acid, (Z)-3-methyl- 9-oxodec-2-enoic acid (4) as well as five known compounds, 10-hydroxykahukuene B (5), pacifenol (6), dysidamide (7), 7,7,7-trichloro-3-hydroxy-2,2,6-trimethyl-4-(4,4,4-trichloro3-methyl-1-oxobu-tylamino)-heptanoic acid methyl ester (8), and the primary metabolite 2’-deoxynucleoside thymidine (9), have been isolated from the Red Sea sponge Spongia sp. The stereoisomer of 3 was discovered in Ganoderma resinaceum, and metabolites 5 and 6, isolated previously from red algae, were characterized unprecedentedly in the sponge. Compounds 7 and 8 have not been found before in the genus Spongia. Compounds 1−9 were also assayed for cytotoxicity as well as antibacterial and anti-inflammatory activities.
AB - A polyoxygenated and halogenated labdane, spongianol (1); a polyoxygenated steroid, 3β,5α,9α-trihydroxy-24S-ethylcholest-7-en-6-one (2); a rare seven-membered lactone B ring, (22E,24S)-ergosta-7,22-dien-3β,5α-diol-6,5-olide (3); and an α,β-unsaturated fatty acid, (Z)-3-methyl- 9-oxodec-2-enoic acid (4) as well as five known compounds, 10-hydroxykahukuene B (5), pacifenol (6), dysidamide (7), 7,7,7-trichloro-3-hydroxy-2,2,6-trimethyl-4-(4,4,4-trichloro3-methyl-1-oxobu-tylamino)-heptanoic acid methyl ester (8), and the primary metabolite 2’-deoxynucleoside thymidine (9), have been isolated from the Red Sea sponge Spongia sp. The stereoisomer of 3 was discovered in Ganoderma resinaceum, and metabolites 5 and 6, isolated previously from red algae, were characterized unprecedentedly in the sponge. Compounds 7 and 8 have not been found before in the genus Spongia. Compounds 1−9 were also assayed for cytotoxicity as well as antibacterial and anti-inflammatory activities.
KW - Anti-inflammatory assay
KW - Antibacterial assay
KW - Cytotoxicity
KW - Fatty acid
KW - Halogenated labdane diterpenoid
KW - Polychlorinated metabolites
KW - Polyoxygenated steroid
KW - Red Sea sponge
KW - Spongia sp
UR - http://www.scopus.com/inward/record.url?scp=85128620919&partnerID=8YFLogxK
U2 - 10.3390/md20040241
DO - 10.3390/md20040241
M3 - 文章
C2 - 35447914
AN - SCOPUS:85128620919
SN - 1660-3397
VL - 20
JO - Marine Drugs
JF - Marine Drugs
IS - 4
M1 - 241
ER -
