The clinical significance of monitoring whole blood concentration of CsA in renal transplant recipients

Whole blood concentration of CsA was assayed 2312 times in 274 renal transplant recipients by the fluorescence polarization immunoassay (FPIA, abbott TDx). In the 1st, 2nd, 3rd and 4 ~ 12 th month post kidney transplantation, the ideal therapeutic window range of whole blood CsA level was 300~430, 280~350, 180~280 and 110~250 ng/ml respectively for patients on triple immuno-suppressive therapy. FPIA was precise, sensitive, rapid and easy to carry out. The correlation among hepatoxicity, nephrotoxicity of CsA, rejection, old and risk recipients and whole blood CsA level was discussed.