The clinicopathological significance of p53 and p21 expression in squamous cell carcinoma of hypopharyngeal cancer

Chih Yen Chien; Chao Cheng Huang; Jiin Tsuey Cheng; Ching Mei Chen; Chung Feng Hwang; Chih Ying Su

doi:10.1016/S0304-3835(03)00484-1

The clinicopathological significance of p53 and p21 expression in squamous cell carcinoma of hypopharyngeal cancer

Chih Yen Chien
, Chao Cheng Huang
, Jiin Tsuey Cheng
, Ching Mei Chen
, Chung Feng Hwang
, Chih Ying Su^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

13 Scopus citations

Abstract

To evaluate the roles of p53 and p21 expression in the squamous cell carcinoma of hypopharyngeal cancer, we performed the immunohistochemical studies in 58 patients with hypopharyngeal cancer. We found significant correlation between a high expression of p53 and a histological grade of well differentiation, advanced tumor (T) and TNM stage. Furthermore, low expression of p21 correlated significantly with advanced TNM stage and positive nodal status. Cox's regression analysis revealed tumor stage and nodal status were the only prognostic factors for survival. Therefore, we concluded that p53 and p21 are useful markers in predicting some clinicopathological features in hypopharyngeal cancer.

Original language	English
Pages (from-to)	217-223
Number of pages	7
Journal	Cancer Letters
Volume	201
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(03)00484-1
State	Published - 14 11 2003
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Hypopharyngeal cancer
p21
p53

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10.1016/S0304-3835(03)00484-1

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title = "The clinicopathological significance of p53 and p21 expression in squamous cell carcinoma of hypopharyngeal cancer",

abstract = "To evaluate the roles of p53 and p21 expression in the squamous cell carcinoma of hypopharyngeal cancer, we performed the immunohistochemical studies in 58 patients with hypopharyngeal cancer. We found significant correlation between a high expression of p53 and a histological grade of well differentiation, advanced tumor (T) and TNM stage. Furthermore, low expression of p21 correlated significantly with advanced TNM stage and positive nodal status. Cox's regression analysis revealed tumor stage and nodal status were the only prognostic factors for survival. Therefore, we concluded that p53 and p21 are useful markers in predicting some clinicopathological features in hypopharyngeal cancer.",

keywords = "Hypopharyngeal cancer, p21, p53",

author = "Chien, \{Chih Yen\} and Huang, \{Chao Cheng\} and Cheng, \{Jiin Tsuey\} and Chen, \{Ching Mei\} and Hwang, \{Chung Feng\} and Su, \{Chih Ying\}",

year = "2003",

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day = "14",

doi = "10.1016/S0304-3835(03)00484-1",

language = "英语",

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TY - JOUR

T1 - The clinicopathological significance of p53 and p21 expression in squamous cell carcinoma of hypopharyngeal cancer

AU - Chien, Chih Yen

AU - Huang, Chao Cheng

AU - Cheng, Jiin Tsuey

AU - Chen, Ching Mei

AU - Hwang, Chung Feng

AU - Su, Chih Ying

PY - 2003/11/14

Y1 - 2003/11/14

N2 - To evaluate the roles of p53 and p21 expression in the squamous cell carcinoma of hypopharyngeal cancer, we performed the immunohistochemical studies in 58 patients with hypopharyngeal cancer. We found significant correlation between a high expression of p53 and a histological grade of well differentiation, advanced tumor (T) and TNM stage. Furthermore, low expression of p21 correlated significantly with advanced TNM stage and positive nodal status. Cox's regression analysis revealed tumor stage and nodal status were the only prognostic factors for survival. Therefore, we concluded that p53 and p21 are useful markers in predicting some clinicopathological features in hypopharyngeal cancer.

AB - To evaluate the roles of p53 and p21 expression in the squamous cell carcinoma of hypopharyngeal cancer, we performed the immunohistochemical studies in 58 patients with hypopharyngeal cancer. We found significant correlation between a high expression of p53 and a histological grade of well differentiation, advanced tumor (T) and TNM stage. Furthermore, low expression of p21 correlated significantly with advanced TNM stage and positive nodal status. Cox's regression analysis revealed tumor stage and nodal status were the only prognostic factors for survival. Therefore, we concluded that p53 and p21 are useful markers in predicting some clinicopathological features in hypopharyngeal cancer.

KW - Hypopharyngeal cancer

KW - p21

KW - p53

UR - https://www.scopus.com/pages/publications/0242332765

U2 - 10.1016/S0304-3835(03)00484-1

DO - 10.1016/S0304-3835(03)00484-1

M3 - 文章

C2 - 14607337

AN - SCOPUS:0242332765

SN - 0304-3835

VL - 201

SP - 217

EP - 223

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

The clinicopathological significance of p53 and p21 expression in squamous cell carcinoma of hypopharyngeal cancer

Abstract

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Keywords

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