TY - JOUR
T1 - The development of antibody-based immunotherapy for methamphetamine abuse
T2 - Immunization, and virus-mediated gene transfer approaches
AU - Chen, Yun Hsiang
AU - Chen, Chia Hsiang
PY - 2013
Y1 - 2013
N2 - Methamphetamine is a highly addictive psychostimulant that has been seriously abused worldwide, and currently there are no approved medications for the treatment of its abuse. Conventional treatments for drug addiction mainly seek to use small molecule agonists or antagonists to target the drug receptors in the brain, but unfortunately it is difficult to find a similar small molecule for the treatment of methamphetamine dependence. Alternatively, anti-methamphetamine antibodies can sequester the drug in the bloodstream and reduce the amount of drug available to the central nervous system, acting as peripheral pharmacokinetic antagonists. This review describes the development of antibody-based immunotherapies, classified into active and passive immunizations, for the treatment of methamphetamine addiction. Furthermore, an alternative therapeutic approach, using a recombinant adeno-associated virus-mediated gene transfer technique to achieve in vivo expression of characterized anti-methamphetamine monoclonal antibodies, is proposed in this article.
AB - Methamphetamine is a highly addictive psychostimulant that has been seriously abused worldwide, and currently there are no approved medications for the treatment of its abuse. Conventional treatments for drug addiction mainly seek to use small molecule agonists or antagonists to target the drug receptors in the brain, but unfortunately it is difficult to find a similar small molecule for the treatment of methamphetamine dependence. Alternatively, anti-methamphetamine antibodies can sequester the drug in the bloodstream and reduce the amount of drug available to the central nervous system, acting as peripheral pharmacokinetic antagonists. This review describes the development of antibody-based immunotherapies, classified into active and passive immunizations, for the treatment of methamphetamine addiction. Furthermore, an alternative therapeutic approach, using a recombinant adeno-associated virus-mediated gene transfer technique to achieve in vivo expression of characterized anti-methamphetamine monoclonal antibodies, is proposed in this article.
KW - Adeno-associated virus
KW - Antibody
KW - Gene therapy
KW - Immunization
KW - Methamphetamine abuse
KW - Vaccine
UR - http://www.scopus.com/inward/record.url?scp=84873200802&partnerID=8YFLogxK
U2 - 10.2174/156652313804806552
DO - 10.2174/156652313804806552
M3 - 文献综述
C2 - 23157545
AN - SCOPUS:84873200802
SN - 1566-5232
VL - 13
SP - 39
EP - 50
JO - Current Gene Therapy
JF - Current Gene Therapy
IS - 1
ER -