The dominant role of forkhead box proteins in cancer

Duc Hiep Bach; Nguyen Phuoc Long; Thi Thu Trang Luu; Nguyen Hoang Anh; Sung Won Kwon; Sang Kook Lee

doi:10.3390/ijms19103279

The dominant role of forkhead box proteins in cancer

Duc Hiep Bach^*
, Nguyen Phuoc Long
, Thi Thu Trang Luu
, Nguyen Hoang Anh
, Sung Won Kwon
, Sang Kook Lee

^*Corresponding author for this work

Seoul National University
University of Texas MD Anderson Cancer Center
College of Pharmacy

Research output: Contribution to journal › Review article › peer-review

93 Scopus citations

Abstract

Forkhead box (FOX) proteins are multifaceted transcription factors that are significantly implicated in cancer, with various critical roles in biological processes. Herein, we provide an overview of several key members of the FOXA, FOXC, FOXM1, FOXO and FOXP subfamilies. Important pathophysiological processes of FOX transcription factors at multiple levels in a context-dependent manner are discussed. We also specifically summarize some major aspects of FOX transcription factors in association with cancer research such as drug resistance, tumor growth, genomic alterations or drivers of initiation. Finally, we suggest that targeting FOX proteins may be a potential therapeutic strategy to combat cancer.

Original language	English
Article number	3279
Journal	International Journal of Molecular Sciences
Volume	19
Issue number	10
DOIs	https://doi.org/10.3390/ijms19103279
State	Published - 22 10 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Drug resistance
FOX proteins
FOXA
FOXC
FOXO-FOXM1
FOXP
Genomic alterations
Hallmarks of cancer
MiRNAs

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10.3390/ijms19103279

Cite this

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title = "The dominant role of forkhead box proteins in cancer",

abstract = "Forkhead box (FOX) proteins are multifaceted transcription factors that are significantly implicated in cancer, with various critical roles in biological processes. Herein, we provide an overview of several key members of the FOXA, FOXC, FOXM1, FOXO and FOXP subfamilies. Important pathophysiological processes of FOX transcription factors at multiple levels in a context-dependent manner are discussed. We also specifically summarize some major aspects of FOX transcription factors in association with cancer research such as drug resistance, tumor growth, genomic alterations or drivers of initiation. Finally, we suggest that targeting FOX proteins may be a potential therapeutic strategy to combat cancer.",

keywords = "Drug resistance, FOX proteins, FOXA, FOXC, FOXO-FOXM1, FOXP, Genomic alterations, Hallmarks of cancer, MiRNAs",

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note = "Publisher Copyright: {\textcopyright} 2018 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2018",

month = oct,

day = "22",

doi = "10.3390/ijms19103279",

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T1 - The dominant role of forkhead box proteins in cancer

AU - Bach, Duc Hiep

AU - Long, Nguyen Phuoc

AU - Luu, Thi Thu Trang

AU - Anh, Nguyen Hoang

AU - Kwon, Sung Won

AU - Lee, Sang Kook

PY - 2018/10/22

Y1 - 2018/10/22

N2 - Forkhead box (FOX) proteins are multifaceted transcription factors that are significantly implicated in cancer, with various critical roles in biological processes. Herein, we provide an overview of several key members of the FOXA, FOXC, FOXM1, FOXO and FOXP subfamilies. Important pathophysiological processes of FOX transcription factors at multiple levels in a context-dependent manner are discussed. We also specifically summarize some major aspects of FOX transcription factors in association with cancer research such as drug resistance, tumor growth, genomic alterations or drivers of initiation. Finally, we suggest that targeting FOX proteins may be a potential therapeutic strategy to combat cancer.

AB - Forkhead box (FOX) proteins are multifaceted transcription factors that are significantly implicated in cancer, with various critical roles in biological processes. Herein, we provide an overview of several key members of the FOXA, FOXC, FOXM1, FOXO and FOXP subfamilies. Important pathophysiological processes of FOX transcription factors at multiple levels in a context-dependent manner are discussed. We also specifically summarize some major aspects of FOX transcription factors in association with cancer research such as drug resistance, tumor growth, genomic alterations or drivers of initiation. Finally, we suggest that targeting FOX proteins may be a potential therapeutic strategy to combat cancer.

KW - Drug resistance

KW - FOX proteins

KW - FOXA

KW - FOXC

KW - FOXO-FOXM1

KW - FOXP

KW - Genomic alterations

KW - Hallmarks of cancer

KW - MiRNAs

UR - https://www.scopus.com/pages/publications/85055514190

U2 - 10.3390/ijms19103279

DO - 10.3390/ijms19103279

M3 - 文献综述

C2 - 30360388

AN - SCOPUS:85055514190

SN - 1661-6596

VL - 19

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 10

M1 - 3279

ER -

The dominant role of forkhead box proteins in cancer

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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