The effect of endogenous nitric oxide on neurogenic plasma exudation in guinea-pig airways

Kuo Han-Pin; Liu Shufang; Peter J. Barnes

doi:10.1016/0014-2999(92)90728-M

The effect of endogenous nitric oxide on neurogenic plasma exudation in guinea-pig airways

Kuo Han-Pin, Liu Shufang, Peter J. Barnes^*

^*Corresponding author for this work

Imperial College London

Research output: Contribution to journal › Journal Article › peer-review

112 Scopus citations

Abstract

We studied the effect of endogenous nitric oxide (NO) on vagally induced plasma exudation into guinea-pig trachea and main bronchi using ¹²⁵I-albumin as a plasma marker. N^G-Nitro-L-arginine methyl ester (L-NAME, 1-10 mg/kg) dose dependently inhibited neurogenic plasma exudation. Intravenous phenylephrine which simulated the vasopressor effect as L-NAME (10 mg/kg) was without effect. The effect of L-NAME (5 mg/kg) was reversed by L-arginine (50 mg/kg). These results suggest that endogenous NO may contribute to neurogenic inflammation in the airways.

Original language	English
Pages (from-to)	385-388
Number of pages	4
Journal	European Journal of Pharmacology
Volume	221
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(92)90728-M
State	Published - 20 10 1992
Externally published	Yes

Keywords

Airways
NANC nerves
Neurogenic inflammation
Nitric oxide (NO)
Plasma exudation
Vagus nerve

Access to Document

10.1016/0014-2999(92)90728-M

Cite this

@article{a6f03404566c45d79f774298ca292234,

title = "The effect of endogenous nitric oxide on neurogenic plasma exudation in guinea-pig airways",

abstract = "We studied the effect of endogenous nitric oxide (NO) on vagally induced plasma exudation into guinea-pig trachea and main bronchi using 125I-albumin as a plasma marker. NG-Nitro-L-arginine methyl ester (L-NAME, 1-10 mg/kg) dose dependently inhibited neurogenic plasma exudation. Intravenous phenylephrine which simulated the vasopressor effect as L-NAME (10 mg/kg) was without effect. The effect of L-NAME (5 mg/kg) was reversed by L-arginine (50 mg/kg). These results suggest that endogenous NO may contribute to neurogenic inflammation in the airways.",

keywords = "Airways, NANC nerves, Neurogenic inflammation, Nitric oxide (NO), Plasma exudation, Vagus nerve",

author = "Kuo Han-Pin and Liu Shufang and Barnes, {Peter J.}",

year = "1992",

month = oct,

day = "20",

doi = "10.1016/0014-2999(92)90728-M",

language = "英语",

volume = "221",

pages = "385--388",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier B.V.",

number = "2-3",

}

TY - JOUR

T1 - The effect of endogenous nitric oxide on neurogenic plasma exudation in guinea-pig airways

AU - Han-Pin, Kuo

AU - Shufang, Liu

AU - Barnes, Peter J.

PY - 1992/10/20

Y1 - 1992/10/20

N2 - We studied the effect of endogenous nitric oxide (NO) on vagally induced plasma exudation into guinea-pig trachea and main bronchi using 125I-albumin as a plasma marker. NG-Nitro-L-arginine methyl ester (L-NAME, 1-10 mg/kg) dose dependently inhibited neurogenic plasma exudation. Intravenous phenylephrine which simulated the vasopressor effect as L-NAME (10 mg/kg) was without effect. The effect of L-NAME (5 mg/kg) was reversed by L-arginine (50 mg/kg). These results suggest that endogenous NO may contribute to neurogenic inflammation in the airways.

AB - We studied the effect of endogenous nitric oxide (NO) on vagally induced plasma exudation into guinea-pig trachea and main bronchi using 125I-albumin as a plasma marker. NG-Nitro-L-arginine methyl ester (L-NAME, 1-10 mg/kg) dose dependently inhibited neurogenic plasma exudation. Intravenous phenylephrine which simulated the vasopressor effect as L-NAME (10 mg/kg) was without effect. The effect of L-NAME (5 mg/kg) was reversed by L-arginine (50 mg/kg). These results suggest that endogenous NO may contribute to neurogenic inflammation in the airways.

KW - Airways

KW - NANC nerves

KW - Neurogenic inflammation

KW - Nitric oxide (NO)

KW - Plasma exudation

KW - Vagus nerve

UR - http://www.scopus.com/inward/record.url?scp=0026767580&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(92)90728-M

DO - 10.1016/0014-2999(92)90728-M

M3 - 文章

C2 - 1426015

AN - SCOPUS:0026767580

SN - 0014-2999

VL - 221

SP - 385

EP - 388

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 2-3

ER -

The effect of endogenous nitric oxide on neurogenic plasma exudation in guinea-pig airways

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this