The effects of weekly alendronate therapy in Taiwanese males with osteoporosis

Jawl Shan Hwang, Miaw Jene Liou, Cheng Ho, Jen Der Lin, Yu Yao Huang, Chao Jan Wang, Keh Sung Tsai, Jung Fu Chen*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

16 Scopus citations


The aim of this study was to evaluate the efficacy, safety, and tolerability of weekly alendronate administration on male osteoporosis in Taiwan. This 6-month, randomized, open-label controlled trial enrolled 46 men with osteoporosis who were randomized to either 70 mg alendronate once weekly (n = 23) or control (n = 23). Bone mineral density (BMD) of lumbar spine and hip and biochemical bone turnover markers were measured; adverse events and tolerability were assessed. Subjects treated with alendronate showed a significant increase in BMD of 5.5% (vs. 2% in control group) at the lumbar spine and 2.7% (vs. 0.7%) at the femoral neck (P<0.05) at 6 months, respectively. There were also significant decreases in serum level of bone formation marker (bone-specific alkaline phosphatase) and urinary excretion of bone resorption marker (deoxypyridinoline) at 3 and 6 months. Thus, alendronate showed anti-osteoporotic effects by increasing BMD and decreasing the concentrations of bone markers. The adverse events were mild and showed no significant difference between the two groups on safety assessments.

Original languageEnglish
Pages (from-to)328-333
Number of pages6
JournalJournal of Bone and Mineral Metabolism
Issue number3
StatePublished - 05 2010


  • Alendronate
  • Bone mineral density
  • Male osteoporosis


Dive into the research topics of 'The effects of weekly alendronate therapy in Taiwanese males with osteoporosis'. Together they form a unique fingerprint.

Cite this