The expression of mammaglobin mRNA in peripheral blood of metastatic breast cancer patients as an adjunct to serum tumor markers

Yung Chang Lin; Yah Huei Wu Chou; I. Ching Liao; Ann Joy Cheng

doi:10.1016/S0304-3835(02)00545-1

The expression of mammaglobin mRNA in peripheral blood of metastatic breast cancer patients as an adjunct to serum tumor markers

Yung Chang Lin
, Yah Huei Wu Chou
, I. Ching Liao
, Ann Joy Cheng^*

^*Corresponding author for this work

Department of Medical Biotechnology and Laboratory Science

Chang Gung Memorial Hospital

Research output: Contribution to journal › Journal Article › peer-review

23 Scopus citations

Abstract

We conducted a study to compare the expression of human mammaglobin (hMAM) mRNA in breast cancer patients' peripheral blood with serum carcinoembryonic antigen (CEA) and CA 15.3. A total of 33 metastatic breast cancer patients were enrolled. The blood samples were used to test the expression of hMAM mRNA by reverse transcriptase polymerase chain reaction (RT-PCR) and CEA, CA 15.3 by radioimmunoassay. The serum CEA and CA 15.3 levels were elevated in 17 (51%) and 23 (69%) of the patients, respectively. When combined CEA with CA 15.3, the sensitivity rate raised to 78%. hMAM mRNA was detected in 18 (54%) of the 33 patients. When combined hMAM mRNA with CEA or CA 15.3, the sensitivity rate were 81% and 90%, respectively (P=0.045). In conclusion, the hMAM mRNA RT-PCR can be an adjunct in detecting metastatic breast cancer.

Original language	English
Pages (from-to)	93-99
Number of pages	7
Journal	Cancer Letters
Volume	191
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(02)00545-1
State	Published - 28 02 2003

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Breast cancer
CA15.3
Carcinoembryonic antigen
Mammaglobin
Metastasis

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10.1016/S0304-3835(02)00545-1

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title = "The expression of mammaglobin mRNA in peripheral blood of metastatic breast cancer patients as an adjunct to serum tumor markers",

abstract = "We conducted a study to compare the expression of human mammaglobin (hMAM) mRNA in breast cancer patients' peripheral blood with serum carcinoembryonic antigen (CEA) and CA 15.3. A total of 33 metastatic breast cancer patients were enrolled. The blood samples were used to test the expression of hMAM mRNA by reverse transcriptase polymerase chain reaction (RT-PCR) and CEA, CA 15.3 by radioimmunoassay. The serum CEA and CA 15.3 levels were elevated in 17 (51\%) and 23 (69\%) of the patients, respectively. When combined CEA with CA 15.3, the sensitivity rate raised to 78\%. hMAM mRNA was detected in 18 (54\%) of the 33 patients. When combined hMAM mRNA with CEA or CA 15.3, the sensitivity rate were 81\% and 90\%, respectively (P=0.045). In conclusion, the hMAM mRNA RT-PCR can be an adjunct in detecting metastatic breast cancer.",

keywords = "Breast cancer, CA15.3, Carcinoembryonic antigen, Mammaglobin, Metastasis",

author = "Lin, \{Yung Chang\} and Chou, \{Yah Huei Wu\} and Liao, \{I. Ching\} and Cheng, \{Ann Joy\}",

year = "2003",

month = feb,

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doi = "10.1016/S0304-3835(02)00545-1",

language = "英语",

volume = "191",

pages = "93--99",

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T1 - The expression of mammaglobin mRNA in peripheral blood of metastatic breast cancer patients as an adjunct to serum tumor markers

AU - Lin, Yung Chang

AU - Chou, Yah Huei Wu

AU - Liao, I. Ching

AU - Cheng, Ann Joy

PY - 2003/2/28

Y1 - 2003/2/28

N2 - We conducted a study to compare the expression of human mammaglobin (hMAM) mRNA in breast cancer patients' peripheral blood with serum carcinoembryonic antigen (CEA) and CA 15.3. A total of 33 metastatic breast cancer patients were enrolled. The blood samples were used to test the expression of hMAM mRNA by reverse transcriptase polymerase chain reaction (RT-PCR) and CEA, CA 15.3 by radioimmunoassay. The serum CEA and CA 15.3 levels were elevated in 17 (51%) and 23 (69%) of the patients, respectively. When combined CEA with CA 15.3, the sensitivity rate raised to 78%. hMAM mRNA was detected in 18 (54%) of the 33 patients. When combined hMAM mRNA with CEA or CA 15.3, the sensitivity rate were 81% and 90%, respectively (P=0.045). In conclusion, the hMAM mRNA RT-PCR can be an adjunct in detecting metastatic breast cancer.

AB - We conducted a study to compare the expression of human mammaglobin (hMAM) mRNA in breast cancer patients' peripheral blood with serum carcinoembryonic antigen (CEA) and CA 15.3. A total of 33 metastatic breast cancer patients were enrolled. The blood samples were used to test the expression of hMAM mRNA by reverse transcriptase polymerase chain reaction (RT-PCR) and CEA, CA 15.3 by radioimmunoassay. The serum CEA and CA 15.3 levels were elevated in 17 (51%) and 23 (69%) of the patients, respectively. When combined CEA with CA 15.3, the sensitivity rate raised to 78%. hMAM mRNA was detected in 18 (54%) of the 33 patients. When combined hMAM mRNA with CEA or CA 15.3, the sensitivity rate were 81% and 90%, respectively (P=0.045). In conclusion, the hMAM mRNA RT-PCR can be an adjunct in detecting metastatic breast cancer.

KW - Breast cancer

KW - CA15.3

KW - Carcinoembryonic antigen

KW - Mammaglobin

KW - Metastasis

UR - https://www.scopus.com/pages/publications/0344642968

U2 - 10.1016/S0304-3835(02)00545-1

DO - 10.1016/S0304-3835(02)00545-1

M3 - 文章

C2 - 12609714

AN - SCOPUS:0344642968

SN - 0304-3835

VL - 191

SP - 93

EP - 99

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

The expression of mammaglobin mRNA in peripheral blood of metastatic breast cancer patients as an adjunct to serum tumor markers

Abstract

UN SDGs

Keywords

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