The first bis-retrochalcone from fissistigma latifolium

Yu Hsuan Lan; Yann Lii Leu; Yi Ting Peng; Tran Dinh Thang; Chia Chen Lin; Bo Ying Bao

doi:10.1055/s-0031-1280088

The first bis-retrochalcone from fissistigma latifolium

Yu Hsuan Lan^*, Yann Lii Leu, Yi Ting Peng, Tran Dinh Thang, Chia Chen Lin, Bo Ying Bao

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

16 Scopus citations

Abstract

Two novel chalconoids, [33]bi-2-hydroxy-4,5,6-trimethoxydihydrochalcone (1) and 4,6-dimethoxy-2,5-quinodihydrochalcone (2), and twelve known compounds were isolated from the methanolic extract of Fissistigma latifolium (Dun.) Merr. The structures of all compounds were determined by spectroscopic methods. Of these, compounds 1, 2, and 2-hydroxy-4,5,6-trimethoxydihydrochalcone (10) belong to an uncommon group of chalconoids, the retrochalcones. Compound 1 is the first bis-retrochalcone to be reported, and compound 2 is a quinoretrochalcone. Furthermore, 2 showed activity against the MDA-MB-231 human breast cancer cell line with an IC ₅₀ value of 7.1μ M.

Original language	English
Pages (from-to)	2019-2022
Number of pages	4
Journal	Planta Medica
Volume	77
Issue number	18
DOIs	https://doi.org/10.1055/s-0031-1280088
State	Published - 2011

Keywords

Annonaceae
Fissistigma latifolium
chalcone
cytotoxicity
retrochalcone

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1055/s-0031-1280088

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title = "The first bis-retrochalcone from fissistigma latifolium",

abstract = "Two novel chalconoids, [33]bi-2-hydroxy-4,5,6-trimethoxydihydrochalcone (1) and 4,6-dimethoxy-2,5-quinodihydrochalcone (2), and twelve known compounds were isolated from the methanolic extract of Fissistigma latifolium (Dun.) Merr. The structures of all compounds were determined by spectroscopic methods. Of these, compounds 1, 2, and 2-hydroxy-4,5,6-trimethoxydihydrochalcone (10) belong to an uncommon group of chalconoids, the retrochalcones. Compound 1 is the first bis-retrochalcone to be reported, and compound 2 is a quinoretrochalcone. Furthermore, 2 showed activity against the MDA-MB-231 human breast cancer cell line with an IC 50 value of 7.1μ M.",

keywords = "Annonaceae, Fissistigma latifolium, chalcone, cytotoxicity, retrochalcone",

author = "Lan, {Yu Hsuan} and Leu, {Yann Lii} and Peng, {Yi Ting} and Thang, {Tran Dinh} and Lin, {Chia Chen} and Bao, {Bo Ying}",

year = "2011",

doi = "10.1055/s-0031-1280088",

language = "英语",

volume = "77",

pages = "2019--2022",

journal = "Planta Medica",

issn = "0032-0943",

publisher = "Georg Thieme Verlag",

number = "18",

}

TY - JOUR

T1 - The first bis-retrochalcone from fissistigma latifolium

AU - Lan, Yu Hsuan

AU - Leu, Yann Lii

AU - Peng, Yi Ting

AU - Thang, Tran Dinh

AU - Lin, Chia Chen

AU - Bao, Bo Ying

PY - 2011

Y1 - 2011

N2 - Two novel chalconoids, [33]bi-2-hydroxy-4,5,6-trimethoxydihydrochalcone (1) and 4,6-dimethoxy-2,5-quinodihydrochalcone (2), and twelve known compounds were isolated from the methanolic extract of Fissistigma latifolium (Dun.) Merr. The structures of all compounds were determined by spectroscopic methods. Of these, compounds 1, 2, and 2-hydroxy-4,5,6-trimethoxydihydrochalcone (10) belong to an uncommon group of chalconoids, the retrochalcones. Compound 1 is the first bis-retrochalcone to be reported, and compound 2 is a quinoretrochalcone. Furthermore, 2 showed activity against the MDA-MB-231 human breast cancer cell line with an IC 50 value of 7.1μ M.

AB - Two novel chalconoids, [33]bi-2-hydroxy-4,5,6-trimethoxydihydrochalcone (1) and 4,6-dimethoxy-2,5-quinodihydrochalcone (2), and twelve known compounds were isolated from the methanolic extract of Fissistigma latifolium (Dun.) Merr. The structures of all compounds were determined by spectroscopic methods. Of these, compounds 1, 2, and 2-hydroxy-4,5,6-trimethoxydihydrochalcone (10) belong to an uncommon group of chalconoids, the retrochalcones. Compound 1 is the first bis-retrochalcone to be reported, and compound 2 is a quinoretrochalcone. Furthermore, 2 showed activity against the MDA-MB-231 human breast cancer cell line with an IC 50 value of 7.1μ M.

KW - Annonaceae

KW - Fissistigma latifolium

KW - chalcone

KW - cytotoxicity

KW - retrochalcone

UR - http://www.scopus.com/inward/record.url?scp=84155167712&partnerID=8YFLogxK

U2 - 10.1055/s-0031-1280088

DO - 10.1055/s-0031-1280088

M3 - 文章

C2 - 21850609

AN - SCOPUS:84155167712

SN - 0032-0943

VL - 77

SP - 2019

EP - 2022

JO - Planta Medica

JF - Planta Medica

IS - 18

ER -

The first bis-retrochalcone from fissistigma latifolium

Abstract

Keywords

UN SDGs

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