The genome of serotype VI Streptococcus agalactiae serotype VI and comparative analysis

En Ming He; Cheng Wen Chen; Yong Guo; Mei Hua Hsu; Liang Zhang; Hsiu Ling Chen; Guo Ping Zhao; Cheng Hsun Chiu; Yan Zhou

doi:10.1016/j.gene.2016.10.030

The genome of serotype VI Streptococcus agalactiae serotype VI and comparative analysis

En Ming He, Cheng Wen Chen, Yong Guo, Mei Hua Hsu, Liang Zhang, Hsiu Ling Chen, Guo Ping Zhao, Cheng Hsun Chiu^*, Yan Zhou

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

9 Scopus citations

Abstract

Streptococcus agalactiae (GBS) causes serious infections in humans and other species. A total of 25 complete GBS genomes, including the first sequenced serotype VI genome (GBS-M002), were compared in this study. The power law model suggested that the pan-genome of GBS is open, with approximately 1300 genes in the core genome of GBS, accounting for approximately 60% of the average genome content. GBS-M002 has 73 specific genes and is one of the five strains containing > 60 specific genes. Based on COG (Cluster of Orthologous Groups of proteins) functional classification, 24% of the genes related to defense mechanisms are specific among the strains. A phylogenetic tree shows that GBS-M002 is closely related to certain strains of serotypes III and V from humans and to isolates of unknown serotype from dog and bovine hosts, suggesting the universal infection potential of GBS from humans to other mammal and fish hosts.

Original language	English
Pages (from-to)	59-65
Number of pages	7
Journal	Gene
Volume	597
DOIs	https://doi.org/10.1016/j.gene.2016.10.030
State	Published - 15 01 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2016 Elsevier B.V.

Keywords

Genomic analysis
Pan-genome
Streptococcus agalactiae

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10.1016/j.gene.2016.10.030

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title = "The genome of serotype VI Streptococcus agalactiae serotype VI and comparative analysis",

abstract = "Streptococcus agalactiae (GBS) causes serious infections in humans and other species. A total of 25 complete GBS genomes, including the first sequenced serotype VI genome (GBS-M002), were compared in this study. The power law model suggested that the pan-genome of GBS is open, with approximately 1300 genes in the core genome of GBS, accounting for approximately 60% of the average genome content. GBS-M002 has 73 specific genes and is one of the five strains containing > 60 specific genes. Based on COG (Cluster of Orthologous Groups of proteins) functional classification, 24% of the genes related to defense mechanisms are specific among the strains. A phylogenetic tree shows that GBS-M002 is closely related to certain strains of serotypes III and V from humans and to isolates of unknown serotype from dog and bovine hosts, suggesting the universal infection potential of GBS from humans to other mammal and fish hosts.",

keywords = "Genomic analysis, Pan-genome, Streptococcus agalactiae",

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year = "2017",

month = jan,

day = "15",

doi = "10.1016/j.gene.2016.10.030",

language = "英语",

volume = "597",

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AU - He, En Ming

AU - Chen, Cheng Wen

AU - Guo, Yong

AU - Hsu, Mei Hua

AU - Zhang, Liang

AU - Chen, Hsiu Ling

AU - Zhao, Guo Ping

AU - Chiu, Cheng Hsun

AU - Zhou, Yan

PY - 2017/1/15

Y1 - 2017/1/15

N2 - Streptococcus agalactiae (GBS) causes serious infections in humans and other species. A total of 25 complete GBS genomes, including the first sequenced serotype VI genome (GBS-M002), were compared in this study. The power law model suggested that the pan-genome of GBS is open, with approximately 1300 genes in the core genome of GBS, accounting for approximately 60% of the average genome content. GBS-M002 has 73 specific genes and is one of the five strains containing > 60 specific genes. Based on COG (Cluster of Orthologous Groups of proteins) functional classification, 24% of the genes related to defense mechanisms are specific among the strains. A phylogenetic tree shows that GBS-M002 is closely related to certain strains of serotypes III and V from humans and to isolates of unknown serotype from dog and bovine hosts, suggesting the universal infection potential of GBS from humans to other mammal and fish hosts.

AB - Streptococcus agalactiae (GBS) causes serious infections in humans and other species. A total of 25 complete GBS genomes, including the first sequenced serotype VI genome (GBS-M002), were compared in this study. The power law model suggested that the pan-genome of GBS is open, with approximately 1300 genes in the core genome of GBS, accounting for approximately 60% of the average genome content. GBS-M002 has 73 specific genes and is one of the five strains containing > 60 specific genes. Based on COG (Cluster of Orthologous Groups of proteins) functional classification, 24% of the genes related to defense mechanisms are specific among the strains. A phylogenetic tree shows that GBS-M002 is closely related to certain strains of serotypes III and V from humans and to isolates of unknown serotype from dog and bovine hosts, suggesting the universal infection potential of GBS from humans to other mammal and fish hosts.

KW - Genomic analysis

KW - Pan-genome

KW - Streptococcus agalactiae

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DO - 10.1016/j.gene.2016.10.030

M3 - 文章

C2 - 27773726

AN - SCOPUS:85002579225

SN - 0378-1119

VL - 597

SP - 59

EP - 65

JO - Gene

JF - Gene

ER -

The genome of serotype VI Streptococcus agalactiae serotype VI and comparative analysis

Abstract

Bibliographical note

Keywords

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