TY - JOUR
T1 - The impact of intrapulmonary shunting after liver transplantation in pediatric patients
AU - Liang, Chi Di
AU - Concejero, Allan
AU - Ko, Sheung Fat
AU - Chen, Chih Cheng
AU - Wang, Chih Chi
AU - Chen, Chao Long
PY - 2012/6
Y1 - 2012/6
N2 - Background/Purpose: Intrapulmonary shunting (IPS) due to pulmonary vascular dilatation is frequently observed among patients with end-stage liver disease (ESLD). This study investigated the prevalence and impact of IPS after liver transplantation (LT) in children. Methods: A total of 77 pediatric patients who underwent primary LT were enrolled. All patients had trans-thoracic contrast echocardiography before LT and at least 1 year after transplantation. The patients with IPS and without IPS after LT were designated as group 1 and group 2, respectively. Results: The prevalence of IPS after LT was 6.1%. The patients in group 1 (n=5) were younger (6.4 +/- 2.8 vs. 9.9 +/- 3.6, p=0.036) than in group 2 (n=72). There were no significant differences in gender, weight, hemoglobin level, O 2 saturation, or complications between the two groups. Fourteen patients had abnormal liver function tests, two patients in group 1 and 12 patients in group 2 (p=0.22).The overall follow-up period was 6.7 +/- 2.7 years (range, 1.6-13.0). At the latest follow-up, all 5 patients with mild IPS after LT remain asymptomatic with good liver graft function. Conclusion: Among pediatric ESLD patients with preoperative IPS, approximately 6% continue to have mild IPS after LT. Patients with mild IPS after LT remain asymptomatic and have good liver graft function.
AB - Background/Purpose: Intrapulmonary shunting (IPS) due to pulmonary vascular dilatation is frequently observed among patients with end-stage liver disease (ESLD). This study investigated the prevalence and impact of IPS after liver transplantation (LT) in children. Methods: A total of 77 pediatric patients who underwent primary LT were enrolled. All patients had trans-thoracic contrast echocardiography before LT and at least 1 year after transplantation. The patients with IPS and without IPS after LT were designated as group 1 and group 2, respectively. Results: The prevalence of IPS after LT was 6.1%. The patients in group 1 (n=5) were younger (6.4 +/- 2.8 vs. 9.9 +/- 3.6, p=0.036) than in group 2 (n=72). There were no significant differences in gender, weight, hemoglobin level, O 2 saturation, or complications between the two groups. Fourteen patients had abnormal liver function tests, two patients in group 1 and 12 patients in group 2 (p=0.22).The overall follow-up period was 6.7 +/- 2.7 years (range, 1.6-13.0). At the latest follow-up, all 5 patients with mild IPS after LT remain asymptomatic with good liver graft function. Conclusion: Among pediatric ESLD patients with preoperative IPS, approximately 6% continue to have mild IPS after LT. Patients with mild IPS after LT remain asymptomatic and have good liver graft function.
KW - Children
KW - Contrast echocardiography
KW - Intrapulmonary shunting
KW - Liver transplantation
UR - http://www.scopus.com/inward/record.url?scp=84862907346&partnerID=8YFLogxK
U2 - 10.1016/j.jfma.2011.03.003
DO - 10.1016/j.jfma.2011.03.003
M3 - 文章
C2 - 22748621
AN - SCOPUS:84862907346
SN - 0929-6646
VL - 111
SP - 315
EP - 319
JO - Journal of the Formosan Medical Association
JF - Journal of the Formosan Medical Association
IS - 6
ER -