The impact of previous ovarian surgery on ovarian reserve in patients with endometriosis

Hsin Ju Chiang, Pin Yao Lin, Fu Jen Huang, Fu Tsai Kung, Yu Ju Lin, Pei Hsun Sung, Kuo Chung Lan*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

14 Scopus citations

Abstract

Background: To investigate the impact of previous ovarian surgery on ovarian reserve in patients with endometriosis. Methods: A total of 829 female patients were recruited. Their medical records were reviewed retrospectively. Patients who had diagnoses of endometriosis or endometrioma were defined as the endometriosis group, and those without endometriosis were as the control group. We further divided these patients into four groups according to whether they had received ovarian surgeries before. Group 1: control group without previous surgery; Group 2: control group with previous surgery; Group 3: endometriosis group without previous surgery; Group 4: endometriosis group with previous surgery. The subgroups with endometrioma or not and different operative procedures were also analyzed. The parameters for comparison included age, body mass index, serum estradiol, follicle-stimulating hormone, luteinizing hormone, cancer antigen 125, and anti-Müllerian hormone (AMH) level. Results: The level of serum AMH was highest in group 1 and lowest in group 4. The decline was significant between group 1 and group 4 (p < 0.05). The serum AMH level was lower in group 4 than in group 3 but no significant difference. Serum estradiol level was significantly higher in group 3 than in group 2 (p < 0.05). Cancer antigen 125 levels were both significantly higher in group 3 and group 4 as compared with group 1 and group 2 (p < 0.05). Conclusions: Performing repeated ovarian surgery in patients with recurrent endometriosis needs careful consideration and adequate patient counselling because of the predictable deteriorating ovarian reserve.

Original languageEnglish
Article number74
JournalBMC Women's Health
Volume15
Issue number1
DOIs
StatePublished - 10 09 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 Chiang et al.

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