The impact of systemic lupus erythematosus on the risk of infection after total hip arthroplasty: A nationwide population-based matched cohort study

Chien Hao Chen, Tien Hsing Chen, Yu Sheng Lin, Dave W. Chen, Chi Chin Sun, Liang Tseng Kuo*, Shih Chieh Shao

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

9 Scopus citations

Abstract

Background: We aimed to assess the impact of systemic lupus erythematosus (SLE) on the risk of infection after total hip arthroplasty (THA). Methods: We identified patients undergoing primary THA (1996-2013) in Taiwan National Health Insurance Research Database (NHIRD). Patients were then divided into the SLE and control groups according to the diagnosis of SLE. We used 1:1 propensity score to match the control to the SLE group by age, sex, and comorbidities. The primary outcome was infection, including early and late superficial wound infection and periprosthetic joint infection (PJI). The secondary outcome was in-hospital complications. Results: We enrolled 325 patients in each group. In the primary outcome, the incidence of early superficial wound infection and PJI was comparable between the SLE and matched-control group. However, the incidence of late superficial wound infection and PJI in the SLE group was higher than that in matched-control group (11.4% vs. 5.5%, P = 0.01; 5.2% vs 2.2%, P = 0.04, respectively). Furthermore, the SLE group had a higher risk for late superficial wound infection and PJI (hazard ratio = 2.37, 95% confidence interval (CI) 1.35-4.16; HR = 2.74, 95% CI 1.14-6.64, respectively) than the matched-control. Complications other than infection and in-hospital mortality cannot be compared because of very low incidence. Conclusions: SLE is a risk factor for developing late superficial wound infection and PJI, but not for early postoperative complications following THA. Clinical presentations should be monitored to avoid misdiagnosis of PJI in SLE patients after THA.

Original languageEnglish
Article number214
JournalArthritis Research and Therapy
Volume22
Issue number1
DOIs
StatePublished - 14 09 2020

Bibliographical note

Publisher Copyright:
© 2020 The Author(s).

Keywords

  • Periprosthetic joint infection
  • Systemic lupus erythematosus
  • Total hip arthroplasty

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