The induction of apoptosis by SV40 T antigen correlates with c-jun overexpression

Show Li Chen*, Yeou Ping Tsao, Yi Liang Chen, Shyh Jer Huang, Junn Liang Chang, Shu Fen Wu

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

24 Scopus citations


Simian virus (SV40) T antigen shares many characteristics with adenovirus E1A which is known to induce apoptosis. To verify the potential of SV40 T antigen-mediated apoptosis, we stably expressed T antigen in immortalized human epithelial cells (Z172 and HaCaT). We found that SV40 T antigen could directly cause apoptosis in 22-27% of these cells under normal growth condition as measured by chromatin condensation and nucleosomal fragmentation. The apoptosis of HaCaT cells which contain mutant p53 suggests the p53-independent nature of T antigen-mediated apoptosis. T antigen- induced apoptosis was associated with increased expression of c-Jun protein. Moreover, the overexpression of c-jun alone in these cells also induced apoptosis, indicating that c-jun might play an important role in T antigen- induced apoptosis.

Original languageEnglish
Pages (from-to)521-529
Number of pages9
Issue number2
StatePublished - 10 05 1998
Externally publishedYes


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