The inhibition of superoxide anion generation by neutrophils from Viscum articulactum

Yann Lii Leu; Shih Ming Kuo; Tsong Long Hwang; Shau Ting Chiu

doi:10.1248/cpb.52.858

The inhibition of superoxide anion generation by neutrophils from Viscum articulactum

Yann Lii Leu^*, Shih Ming Kuo, Tsong Long Hwang, Shau Ting Chiu

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

34 Scopus citations

Abstract

Two new flavanones, (2S)-pinocembrin 7-O-[β-D-apiosyl(1→2)]- β-D-glucoside (1), and (2S)-pinocembrin 7-O-[cinnamoyl(1→5)- β-D-apiosyl(1→2)]- β-D-glucoside (2) together with eighteen known compounds, which include five known flavanones, nine benzenoids, one inositol and three triterpenoids, were isolated and characterized from fresh Viscum articulactum. Structures of new compounds were determined by spectral analysis. Among them, oleanolic acid (18) showed a significant inhibition effect on superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP).

Original language	English
Pages (from-to)	858-860
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	52
Issue number	7
DOIs	https://doi.org/10.1248/cpb.52.858
State	Published - 07 2004

Keywords

Flavanone
Loranthaceae
Viscum articulactum

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10.1248/cpb.52.858

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title = "The inhibition of superoxide anion generation by neutrophils from Viscum articulactum",

abstract = "Two new flavanones, (2S)-pinocembrin 7-O-[β-D-apiosyl(1→2)]- β-D-glucoside (1), and (2S)-pinocembrin 7-O-[cinnamoyl(1→5)- β-D-apiosyl(1→2)]- β-D-glucoside (2) together with eighteen known compounds, which include five known flavanones, nine benzenoids, one inositol and three triterpenoids, were isolated and characterized from fresh Viscum articulactum. Structures of new compounds were determined by spectral analysis. Among them, oleanolic acid (18) showed a significant inhibition effect on superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP).",

keywords = "Flavanone, Loranthaceae, Viscum articulactum",

author = "Leu, {Yann Lii} and Kuo, {Shih Ming} and Hwang, {Tsong Long} and Chiu, {Shau Ting}",

year = "2004",

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doi = "10.1248/cpb.52.858",

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AU - Kuo, Shih Ming

AU - Hwang, Tsong Long

AU - Chiu, Shau Ting

PY - 2004/7

Y1 - 2004/7

N2 - Two new flavanones, (2S)-pinocembrin 7-O-[β-D-apiosyl(1→2)]- β-D-glucoside (1), and (2S)-pinocembrin 7-O-[cinnamoyl(1→5)- β-D-apiosyl(1→2)]- β-D-glucoside (2) together with eighteen known compounds, which include five known flavanones, nine benzenoids, one inositol and three triterpenoids, were isolated and characterized from fresh Viscum articulactum. Structures of new compounds were determined by spectral analysis. Among them, oleanolic acid (18) showed a significant inhibition effect on superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP).

AB - Two new flavanones, (2S)-pinocembrin 7-O-[β-D-apiosyl(1→2)]- β-D-glucoside (1), and (2S)-pinocembrin 7-O-[cinnamoyl(1→5)- β-D-apiosyl(1→2)]- β-D-glucoside (2) together with eighteen known compounds, which include five known flavanones, nine benzenoids, one inositol and three triterpenoids, were isolated and characterized from fresh Viscum articulactum. Structures of new compounds were determined by spectral analysis. Among them, oleanolic acid (18) showed a significant inhibition effect on superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP).

KW - Flavanone

KW - Loranthaceae

KW - Viscum articulactum

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The inhibition of superoxide anion generation by neutrophils from Viscum articulactum

Abstract

Keywords

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