The inhibitory effect of some ionophores on human sperm motility

C. Y. Hong; J. J. Huang; B. N. Chiang; Y. H. Wei

doi:10.1016/0010-7824(86)90021-1

The inhibitory effect of some ionophores on human sperm motility

C. Y. Hong^*
, J. J. Huang
, B. N. Chiang
, Y. H. Wei

^*Corresponding author for this work

Veterans General Hospital-Taipei

Research output: Contribution to journal › Journal Article › peer-review

6 Scopus citations

Abstract

The inhibitory effect of five ionophores, namely, A23187, nonactin, nigericin, monensin and m-chlorocarbonyl cyanide phenylhydrazone, on human sperm motility were measured with a trans-membrane migration method. The concentrations of A23187 and nigericin that decreased sperm motility to 50% of control were 20 μM (10.5 mg/l) and 8 μM (5.8 mg/l), respectively. Because these two ionophores were more potent than previously reported membrane-active sperm-immobilizing agents, we propose that ionophores could be a new category of vaginal contraceptive if a pharmaceutical preparation that is safe to be administered in vivo can be developed.

Original language	English
Pages (from-to)	301-306
Number of pages	6
Journal	Contraception
Volume	33
Issue number	3
DOIs	https://doi.org/10.1016/0010-7824(86)90021-1
State	Published - 03 1986
Externally published	Yes

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10.1016/0010-7824(86)90021-1

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title = "The inhibitory effect of some ionophores on human sperm motility",

abstract = "The inhibitory effect of five ionophores, namely, A23187, nonactin, nigericin, monensin and m-chlorocarbonyl cyanide phenylhydrazone, on human sperm motility were measured with a trans-membrane migration method. The concentrations of A23187 and nigericin that decreased sperm motility to 50\% of control were 20 μM (10.5 mg/l) and 8 μM (5.8 mg/l), respectively. Because these two ionophores were more potent than previously reported membrane-active sperm-immobilizing agents, we propose that ionophores could be a new category of vaginal contraceptive if a pharmaceutical preparation that is safe to be administered in vivo can be developed.",

author = "Hong, \{C. Y.\} and Huang, \{J. J.\} and Chiang, \{B. N.\} and Wei, \{Y. H.\}",

year = "1986",

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doi = "10.1016/0010-7824(86)90021-1",

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TY - JOUR

T1 - The inhibitory effect of some ionophores on human sperm motility

AU - Hong, C. Y.

AU - Huang, J. J.

AU - Chiang, B. N.

AU - Wei, Y. H.

PY - 1986/3

Y1 - 1986/3

N2 - The inhibitory effect of five ionophores, namely, A23187, nonactin, nigericin, monensin and m-chlorocarbonyl cyanide phenylhydrazone, on human sperm motility were measured with a trans-membrane migration method. The concentrations of A23187 and nigericin that decreased sperm motility to 50% of control were 20 μM (10.5 mg/l) and 8 μM (5.8 mg/l), respectively. Because these two ionophores were more potent than previously reported membrane-active sperm-immobilizing agents, we propose that ionophores could be a new category of vaginal contraceptive if a pharmaceutical preparation that is safe to be administered in vivo can be developed.

AB - The inhibitory effect of five ionophores, namely, A23187, nonactin, nigericin, monensin and m-chlorocarbonyl cyanide phenylhydrazone, on human sperm motility were measured with a trans-membrane migration method. The concentrations of A23187 and nigericin that decreased sperm motility to 50% of control were 20 μM (10.5 mg/l) and 8 μM (5.8 mg/l), respectively. Because these two ionophores were more potent than previously reported membrane-active sperm-immobilizing agents, we propose that ionophores could be a new category of vaginal contraceptive if a pharmaceutical preparation that is safe to be administered in vivo can be developed.

UR - https://www.scopus.com/pages/publications/0022458913

U2 - 10.1016/0010-7824(86)90021-1

DO - 10.1016/0010-7824(86)90021-1

M3 - 文章

C2 - 3087696

AN - SCOPUS:0022458913

SN - 0010-7824

VL - 33

SP - 301

EP - 306

JO - Contraception

JF - Contraception

IS - 3

ER -

The inhibitory effect of some ionophores on human sperm motility

Abstract

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