The joint effect of smoking and hOGG1 genotype on oral cancer in Taiwan

Chia Wen Tsai, Ming Hsui Tsai, Yung An Tsou, Liang Chun Shih, Hsien Chang Tseng, Wen Shin Chang, Chien Yi Ho, Hong Zin Lee, Da Tian Bau*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

17 Scopus citations


This study aimed at evaluating the association and interaction among human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) genotypic polymorphism, smoking status and oral cancer risk in Taiwan. For this purpose, the well-known polymorphic variants of hOGG1, codon 326, was analyzed for its association with oral cancer susceptibility, and its joint effect with individual smoking habits on oral cancer susceptibility. In total, 620 patients with oral cancer and 620 healthy controls were recruited from the China Medical Hospital and genotyped. The results showed that the hOGG1 codon 326 genotypes were differently distributed between the oral cancer and control groups (p=0.0266), with the C allele of hOGG1 codon 326 being significantly (p=0.0046) more frequently found in cancer patients than in controls. We further analyzed the genetic-smoking joint effects on oral cancer risk and found an interaction between hOGG1 codon 326 genotypes and smoking status. The hOGG1 codon 326 CC genotype was associated with oral cancer risk only in the smoker group (p=0.0198), but not in the non-chewer group (p=0.8357). Our results provide evidence that the C allele of hOGG1 codon 326 may have a joint effect with smoking on the development of oral cancer.

Original languageEnglish
Pages (from-to)3799-3803
Number of pages5
JournalAnticancer Research
Issue number9
StatePublished - 09 2012
Externally publishedYes


  • Oral cancer
  • Single-nucleotide polymorphism
  • Smoking
  • hOGG1


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