The mannose receptor: Linking homeostasis and immunity through sugar recognition

Philip R. Taylor; Siamon Gordon; Luisa Martinez-Pomares

doi:10.1016/j.it.2004.12.001

The mannose receptor: Linking homeostasis and immunity through sugar recognition

Philip R. Taylor^*
, Siamon Gordon
, Luisa Martinez-Pomares

^*Corresponding author for this work

University of Oxford

Research output: Contribution to journal › Review article › peer-review

318 Citations (SciVal)

Abstract

The mannose receptor (MR) can potentially internalize compounds that are recognized by three binding sites located in its extracellular region. It is subject to proteolytic processing and glycosylation, has a complex expression pattern and exhibits tissue-dependent binding properties. It is not surprising, given this complexity, that the MR has been implicated in homeostatic processes, such as clearance of endogenous products and cell adhesion, as well as pathogen recognition and antigen presentation. In this Review, we summarize the current knowledge regarding the different aspects of MR binding properties, contribution to homeostatic clearance, cell activation and antigen presentation.

Original language	English
Pages (from-to)	104-110
Number of pages	7
Journal	Trends in Immunology
Volume	26
Issue number	2
DOIs	https://doi.org/10.1016/j.it.2004.12.001
State	Published - 02 2005
Externally published	Yes

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title = "The mannose receptor: Linking homeostasis and immunity through sugar recognition",

abstract = "The mannose receptor (MR) can potentially internalize compounds that are recognized by three binding sites located in its extracellular region. It is subject to proteolytic processing and glycosylation, has a complex expression pattern and exhibits tissue-dependent binding properties. It is not surprising, given this complexity, that the MR has been implicated in homeostatic processes, such as clearance of endogenous products and cell adhesion, as well as pathogen recognition and antigen presentation. In this Review, we summarize the current knowledge regarding the different aspects of MR binding properties, contribution to homeostatic clearance, cell activation and antigen presentation.",

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AB - The mannose receptor (MR) can potentially internalize compounds that are recognized by three binding sites located in its extracellular region. It is subject to proteolytic processing and glycosylation, has a complex expression pattern and exhibits tissue-dependent binding properties. It is not surprising, given this complexity, that the MR has been implicated in homeostatic processes, such as clearance of endogenous products and cell adhesion, as well as pathogen recognition and antigen presentation. In this Review, we summarize the current knowledge regarding the different aspects of MR binding properties, contribution to homeostatic clearance, cell activation and antigen presentation.

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M3 - 文献综述

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VL - 26

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EP - 110

JO - Trends in Immunology

JF - Trends in Immunology

IS - 2

ER -

The mannose receptor: Linking homeostasis and immunity through sugar recognition

Abstract

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