TY - JOUR
T1 - The mannose receptor
T2 - Linking homeostasis and immunity through sugar recognition
AU - Taylor, Philip R.
AU - Gordon, Siamon
AU - Martinez-Pomares, Luisa
PY - 2005/2
Y1 - 2005/2
N2 - The mannose receptor (MR) can potentially internalize compounds that are recognized by three binding sites located in its extracellular region. It is subject to proteolytic processing and glycosylation, has a complex expression pattern and exhibits tissue-dependent binding properties. It is not surprising, given this complexity, that the MR has been implicated in homeostatic processes, such as clearance of endogenous products and cell adhesion, as well as pathogen recognition and antigen presentation. In this Review, we summarize the current knowledge regarding the different aspects of MR binding properties, contribution to homeostatic clearance, cell activation and antigen presentation.
AB - The mannose receptor (MR) can potentially internalize compounds that are recognized by three binding sites located in its extracellular region. It is subject to proteolytic processing and glycosylation, has a complex expression pattern and exhibits tissue-dependent binding properties. It is not surprising, given this complexity, that the MR has been implicated in homeostatic processes, such as clearance of endogenous products and cell adhesion, as well as pathogen recognition and antigen presentation. In this Review, we summarize the current knowledge regarding the different aspects of MR binding properties, contribution to homeostatic clearance, cell activation and antigen presentation.
UR - https://www.scopus.com/pages/publications/12744279203
U2 - 10.1016/j.it.2004.12.001
DO - 10.1016/j.it.2004.12.001
M3 - 文献综述
C2 - 15668126
AN - SCOPUS:12744279203
SN - 1471-4906
VL - 26
SP - 104
EP - 110
JO - Trends in Immunology
JF - Trends in Immunology
IS - 2
ER -
