The maturity of human cumulus-free oocytes is positively related to blastocyst development and viability

Fu Jen Huang; Hsuan Wei Huang; Kuo Chung Lan; Fu Tsai Kung; Yi Chi Lin; Hsueh Wen Chang; Shiuh Young Chang

doi:10.1023/A:1021259031267

The maturity of human cumulus-free oocytes is positively related to blastocyst development and viability

Fu Jen Huang, Hsuan Wei Huang, Kuo Chung Lan, Fu Tsai Kung, Yi Chi Lin, Hsueh Wen Chang, Shiuh Young Chang^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

13 Scopus citations

Abstract

Purpose: We investigated whether the human oocyte maturity at the removal of cumulus/corona cells affects the embryo outcome in vitro. Methods: A total of 620 oocytes, which subsequently underwent blastocyst culture, were included in this analysis. Oocytes that were in prophase or Metaphase I of meiosis at the removal of cumulus/corona cells were in Group II. Oocytes that were in Metaphase II at the removal of cumulus/corona cells were in Group I. Results: Group I oocytes yielded the highest fertilization rates (96.3% vs. 77.1%, P < 0.001). The incidence of Group II oocytes developing to the blastocyst stage was significantly less than from Group I oocytes (38.1% vs. 86.1%, P < 0.001). The percentage of top-scoring blastocysts from Group I oocytes was higher than that of Group II oocytes (95.4% vs. 76.2%, P < 0.001). Conclusions: Oocyte maturity at the removal of cumulus/corona cells needs to be considered in selecting good quality blastocysts for embryo transfer.

Original language	English
Pages (from-to)	555-560
Number of pages	6
Journal	Journal of Assisted Reproduction and Genetics
Volume	19
Issue number	12
DOIs	https://doi.org/10.1023/A:1021259031267
State	Published - 01 12 2002
Externally published	Yes

Keywords

Blastocyst development
Cumulus-free oocytes
Fertilization rate
Intrtacytoplasmic sperm injection

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@article{11583f7ab0e5485b9f64b8821b6c34e9,

title = "The maturity of human cumulus-free oocytes is positively related to blastocyst development and viability",

abstract = "Purpose: We investigated whether the human oocyte maturity at the removal of cumulus/corona cells affects the embryo outcome in vitro. Methods: A total of 620 oocytes, which subsequently underwent blastocyst culture, were included in this analysis. Oocytes that were in prophase or Metaphase I of meiosis at the removal of cumulus/corona cells were in Group II. Oocytes that were in Metaphase II at the removal of cumulus/corona cells were in Group I. Results: Group I oocytes yielded the highest fertilization rates (96.3% vs. 77.1%, P < 0.001). The incidence of Group II oocytes developing to the blastocyst stage was significantly less than from Group I oocytes (38.1% vs. 86.1%, P < 0.001). The percentage of top-scoring blastocysts from Group I oocytes was higher than that of Group II oocytes (95.4% vs. 76.2%, P < 0.001). Conclusions: Oocyte maturity at the removal of cumulus/corona cells needs to be considered in selecting good quality blastocysts for embryo transfer.",

keywords = "Blastocyst development, Cumulus-free oocytes, Fertilization rate, Intrtacytoplasmic sperm injection",

author = "Huang, {Fu Jen} and Huang, {Hsuan Wei} and Lan, {Kuo Chung} and Kung, {Fu Tsai} and Lin, {Yi Chi} and Chang, {Hsueh Wen} and Chang, {Shiuh Young}",

year = "2002",

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doi = "10.1023/A:1021259031267",

language = "英语",

volume = "19",

pages = "555--560",

journal = "Journal of Assisted Reproduction and Genetics",

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TY - JOUR

T1 - The maturity of human cumulus-free oocytes is positively related to blastocyst development and viability

AU - Huang, Fu Jen

AU - Huang, Hsuan Wei

AU - Lan, Kuo Chung

AU - Kung, Fu Tsai

AU - Lin, Yi Chi

AU - Chang, Hsueh Wen

AU - Chang, Shiuh Young

PY - 2002/12/1

Y1 - 2002/12/1

N2 - Purpose: We investigated whether the human oocyte maturity at the removal of cumulus/corona cells affects the embryo outcome in vitro. Methods: A total of 620 oocytes, which subsequently underwent blastocyst culture, were included in this analysis. Oocytes that were in prophase or Metaphase I of meiosis at the removal of cumulus/corona cells were in Group II. Oocytes that were in Metaphase II at the removal of cumulus/corona cells were in Group I. Results: Group I oocytes yielded the highest fertilization rates (96.3% vs. 77.1%, P < 0.001). The incidence of Group II oocytes developing to the blastocyst stage was significantly less than from Group I oocytes (38.1% vs. 86.1%, P < 0.001). The percentage of top-scoring blastocysts from Group I oocytes was higher than that of Group II oocytes (95.4% vs. 76.2%, P < 0.001). Conclusions: Oocyte maturity at the removal of cumulus/corona cells needs to be considered in selecting good quality blastocysts for embryo transfer.

AB - Purpose: We investigated whether the human oocyte maturity at the removal of cumulus/corona cells affects the embryo outcome in vitro. Methods: A total of 620 oocytes, which subsequently underwent blastocyst culture, were included in this analysis. Oocytes that were in prophase or Metaphase I of meiosis at the removal of cumulus/corona cells were in Group II. Oocytes that were in Metaphase II at the removal of cumulus/corona cells were in Group I. Results: Group I oocytes yielded the highest fertilization rates (96.3% vs. 77.1%, P < 0.001). The incidence of Group II oocytes developing to the blastocyst stage was significantly less than from Group I oocytes (38.1% vs. 86.1%, P < 0.001). The percentage of top-scoring blastocysts from Group I oocytes was higher than that of Group II oocytes (95.4% vs. 76.2%, P < 0.001). Conclusions: Oocyte maturity at the removal of cumulus/corona cells needs to be considered in selecting good quality blastocysts for embryo transfer.

KW - Blastocyst development

KW - Cumulus-free oocytes

KW - Fertilization rate

KW - Intrtacytoplasmic sperm injection

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DO - 10.1023/A:1021259031267

M3 - 文章

C2 - 12503887

AN - SCOPUS:0036911615

SN - 1058-0468

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SP - 555

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JO - Journal of Assisted Reproduction and Genetics

JF - Journal of Assisted Reproduction and Genetics

IS - 12

ER -

The maturity of human cumulus-free oocytes is positively related to blastocyst development and viability

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